Scalp Hair Metabolomics in Severe Obesity
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age21-70
SponsorSingapore General Hospital
About this trial
The purpose of this research study is to investigate how body weight and weight-loss surgery affect the natural chemicals found in scalp hair over time. We will also find out how common and severe hair thinning/hair loss and muscle loss are in the first 6 months after bariatric surgery.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age 21-70 years
Ability to provide informed consent
BMI of 18.5-24.9 kg/m2
No chronic disease
Disqualifiers
Pregnancy
Any factors likely to limit adherence to study protocol
Any history of autoimmune or scarring alopecia (eg. alopecia areata, discoid lupus, lichen planopilaris)
Trial population
Subjects with severe obesity will be recruited from the Singapore General Hospital's obesity clinic, while controls will be healthy volunteers.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
60 Participants
are grouped into 2 trial groupsGroup A: Healthy controls
Group B: Severe obestiy
Trial outcomes
Primary outcomes
1
Amino acid concentration
Post-surgery changes in scalp hair amino acid concentration following bariatric surgery
Time frame
From enrollment to the end of study duration at 6 monthsSecondary outcomes
1
Severity of hair loss
The severity of hair loss is measured by quantifying the number of hairs lost during the hair pull test
Time frame
From the time of enrolment until the end of the study at 6 months2
Scalp hair amino acid concentration (between groups)
Differences in scalp hair amino acid concentration between controls and those with severe obesity
Time frame
At the time of enrollment3
Grip strength
The post-surgery changes in grip strength measured using handgrip dynamometer
Time frame
From enrollment until the end of the study at 6 months4
Sit to stand speed
Time taken to complete sit to stand test after bariatric surgery
Time frame
From enrollment until study completion at 6 monthsSponsors and contacts
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Source ClinicalTrials.gov