Screening and Secondary Prevention Rheumatic Heart Disease Study

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age10-30
SponsorNational Institute of Cardiovascular Diseases, Pakistan

About this trial

After basic clinical screening including history and physical, Point of care ultrasound will be performed to look at Mitral, Aortic and Tricuspid Valves for regurgitation or stenosis. For patients with confirmed Rheumatic heart disease (RHD), treatment and referral depending on stage of disease. Antibiotic prescription could be shifted to community health workers delivering preventive medications via practical clinical algorithms, diagnostic tools, availability of appropriate antibiotics, and supportive supervision. Patients will have repeat imaging at 2 years and 5 years to look at the outcome of delayed progression of valve disease.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Rural communities in Sindh

Disqualifiers

Refused to participate in the study

Trial population

Age group 10-30 years. Screening in rural communities in Sindh including very low income areas outside Karachi. Schools (free government schools in low income areas) and patient point of contact locations such as National Institute of Cardiovascular Diseases Pakistan Satellite centers (10) and chest pain units (24) will also be utilized. Family members of patients with known rheumatic heart disease will also be screened.

Trial design

Design model

Cohort

Time perspective

Cross-sectional

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Rheumatic heart disease

Number of patients

Time frame
At the time of screening echocardiogram

Secondary outcomes

Other outcomes

Sponsors and contacts

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