Screening of Malignant Hyperthermia Susceptible Individuals
ConditionMalignant Hyperthermia
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age0-100
SponsorPeking University Third Hospital
About this trial
This study intends to target patients who underwent surgery under general anesthesia during the study period and developed malignant hyperthermia during or after surgery. Therefore, the total sample size was estimated to be about 50 people based on the past incidence of this rare disease. Every year, about 20 patients and their families who developed malignant hyperthermia during or after surgery will participate in this nationwide study (estimated by the current incidence of malignant hyperthermia), and about 1-5 patients will be admitted to Peking University Third Hospital participate in this research. Relevant specimens were collected from malignant hyperthermia (MH) patients and their family members for genetic analysis to determine the mutation of MH-related pathogenic gene loci.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients undergoing surgery under general anesthesia during the study period developed malignant hyperthermia during or after surgery.
Disqualifiers
Malignant hyperthermia was ruled out by later treatment and diagnosis;
The patient or family member refuses to be recruited.
Trial population
Since the incidence of malignant hyperthermia is low (1/50,000 in adults, 1/15,000 in children), it is a rare disease, so this study will continue for 10-20 years. This study is an observational study, so the sample is estimated based on the past incidence of this rare disease. The amount is about 50 patients.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Whole exome sequencing
Time frame
immediately after MH was diagnosedSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov