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Sensory and Cognitive Predictions, and Their Disruptions in Schizophrenia

ConditionsSchizophreniaSensory Processing Disorder
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorCentre Psychothérapique de Nancy

About this trial

Disturbances in the sense of self and time could play an important role in the development of psychotic symptoms. Previous work has shown that patients have difficulty preparing to process information on the scale of a second, but are abnormally disturbed by slightly asynchronous information on the millisecond scale. In both cases, the anomalies could explain the patients' unusual experience of time. The hypothesis in neurotypical patients is that small delays or asynchronies asynchronies are treated as irrelevant information and ignored and ignored, whereas in patients suffering from schizophrenia they would disrupt the flow of time. This hypothesis is tested with a new visual illusion.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Male or female;

Age between 18 and 60 inclusive;

Subject having dated and signed the consent form prior to the start of any trial-related procedure (guardian or curator where applicable);

Member of a social security scheme or beneficiary of such a scheme.

Disqualifiers

Psychoactive substance use disorders (as defined by the DSM-V) (Diagnostic and Statistical Manual-V);

Use of benzodiazepines, hallucinogens (in the period preceding before inclusion, for a duration equivalent to 5 half-lives of the product) or cannabis (in the 2 months preceding inclusion);

Neurological pathology or sequelae;

Attention deficit hyperactivity disorder (ADHD);

Trial design

Design model

Single group

Treatments tested in this trial

  • Illusion task

    Behavioral

    The task is the illusion already described in the arm description. All participants will additionally benefit from a short neuropsychological evaluation exploring attention (CPT-AX) and semantic knowledge (fNART) and a clinical evaluation exploring the sense of self (EASE).

Treatment groups

68 Participants
are divided into 1 treatment group
Group A: effect of trajectory perturbationExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Effect of a millisecond-level trajectory perturbation

Change in the rate of illusion in case of a trajectory perturbation (compared to the rate of illusion in the absence of perturbation)

Time frame
Month 4

Secondary outcomes

1

Baseline rate of illusion

Frequency of the illusion perception when there is no trajectory perturbation and no rebound after the collision

Time frame
month 4
2

Effect of a rebound (top-down, conscious influence)

Change in the rate of illusion in case of a rebound (compared to the rate of illusion in the absence of rebound)

Time frame
month 4

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Centre Psychothérapique de Nancy

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Collaborator

Source ClinicalTrials.gov
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