In the proposed research, we will assess motor and sensory functions of the hand using clinical tests and a tool designed to measure manual dexterity combined with vibrotactile stimulation. We will also evaluate the integrity of brain structure and function using MRI.
First symptomatic stroke, ischaemic or haemorrhagic in the early subacute phase (up to 3 weeks post-stroke)
Upper limb paresis (≤4/5 MRC Scale)
Ability to grasp, lift and put down 1 block (from the BBT test)
Be affiliated to a social security
Presence of another neurological or musculoskeletal condition affecting upper limb movement
Severe cognitive impairment and/or aphasia with inability to understand and carry out instructions
Contraindications to MRI (claustrophobia, presence of cochlear implants and/or pacemakers)
Persons subject to legal protection measures
Parallel
Haptic stimulation device
DeviceBoth patients and healthy participants will perform manual dexterity tasks using the Dextrain Manipulandum. In addition, they will receive finger vibrations delivered via rings that we have previously developed. These vibrations will have a frequency of 150 Hz and will be delivered for a duration of 150 ms.
Brain MRI
Other interventionSubjects and patients will undergo anatomical, resting-state functional, and diffusion brain MRI sequences.
Gain in the prediction of manual dexterity recovery
The primary outcome measure is a 10% improvement in the prediction of the Box and Block Test (BBT) score at 3 and 6 months post-stroke achieved by adding the haptic effect to a multivariate model.
Change in the prediction of the Box and Block Test (BBT) score when taking into account the haptic effect during an index finger force control task.
Determine whether the haptic effect calculated during an index finger force control exercise (using the dextrain manipulandum) measured in the acute phase after stroke can improve the prediction of manual dexterity recovery (Box and Blocks Test, BBT) at 3 months and 6 months after stroke.
Predicting recovery in various clinical tests of motor and sensory function and activity limitations at 3 months and 6 months post-stroke.
Determine whether the haptic effect VS absence of haptic effect improves the prediction of recovery from motor impairment (Fugl Mayer Assessment for Upper Extremity FMA-UE, Purdue Pegboard Test), sensitivity (monofilaments and Nottingham Sensory Assessment), and activity limitations (Stroke Impact Scale) of the upper limb from 3 weeks to 3 and 6 months post-stroke.
Difference in functional and structural connectivity between subgroups with vs without haptic effect at 3 and 6 months
Investigate whether connectivity of fronto-parietal networks at 3 weeks post-stroke predicts recovery of haptic effect and dexterity at 3 and 6 months.
Changes in the structural and functional connectivity of fronto-parietal networks between 3 weeks and 6 months post-stroke
A difference in the change in connectivity between subgroups with versus without haptic effect at 6 months will be investigated.
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