Health TrialsbyHealthPanel

Sensory-Motor Integration for Speech Rehabilitation in Patients With Post-stroke Aphasia

ConditionsAphasia Non FluentStroke
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age55-75
SponsorUniversity Hospital, Grenoble

About this trial

SEMO is a multidisciplinary project (language sciences, cognitive psychology and neuropsychology, physical medicine and rehabilitation, neurology, speech-language pathology, functional neuroimaging and engineering sciences) that aims first, to test and develop a novel speech rehabilitation program designed for patients with non-fluent aphasia and, second, to better describe neural reorganization after successful recovery. To this end, the investigators will conduct a prospective monocentric cross-over study, including two cohorts of post-stroke aphasic patients and two control groups.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

patients with non-fluent aphasia after lesion in the dominant hemisphere for language

native speakers of French

normal or corrected to normal vision

satisfying all criteria for the MRI examination

Disqualifiers

patients with comprehension deficits, hemi-spatial neglect or upper limb apraxia

Trial design

Design model

Crossover

Treatments tested in this trial

  • Enriched rehabilitation

    Device

    The enriched rehabilitation is based on the use of sensory-motor integration in addition to conventional speech therapy. The sensory-motor integration method is based on the Ultraspeech-player software. This software allows therapists to display movements of speech articulators (tongue and lips) recorded on a reference speaker during production of vowels or consonants (isolated or combined). Sagittal movements of the tongue are recorded using ultrasound and front views of lip movements are captured through video imaging. During rehabilitation with the Ultraspeech-player software, patients will be seated in front of a computer screen, observe articulatory movements and listen to phonemes. Then, they will be required to repeat each of them five times and move on to the next phoneme, with the agreement of the experimenter.

  • Simple rehabilitation

    Device

    The simple rehabilitation is based on conventional speech therapy. The conventional speech therapy will be provided by the speech therapist. Classically, the speech therapist uses word production with repetition and naming exercises. The therapist will show the patient series of pictures associated or not with written words, and the patient is required to name them and/or read aloud the word. In case of impossibility to perform the task, the therapist may can help the patient by using the indexing method or by asking the patient to repeat after him/her. According to patient's competencies and progress, the difficulty of reeducation can increase progressively.

Treatment groups

80 Participants
are divided into 2 treatment groups
Group A: SE cohortExperimental treatment 2 interventions
Group B: ES cohortExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

Evaluation of acoustic changes in the speech signal before and after each rehabilitation protocol

Assessment of acoustic properties (formants, voice onset time and spectral moments) with a phoneme repetition task. Repeated phonemes are isolated vowels, semi-consonants in vowel context and consonants in /a/ context with the consonants (C) placed in initial (/Ca/) or medial (/aCa/) positions.

Time frame
Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention

Secondary outcomes

1

Evaluation of changes in inner speech abilities before and after each rehabilitation protocol - Inner speech testing 1

Evaluate inner speech abilities with an introspective questionnaire

Time frame
Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention
2

Evaluation of changes in inner speech abilities before and after each rehabilitation protocol - Inner speech testing 2

Evaluate inner speech abilities with a behavioral task (homophone detection task)

Time frame
Baseline pre-intervention; immediately after the first intervention; immediately after the second intervention
3

Clinical language assessment 1a

Assessment of oral and written expression with BDAE (Boston Diagnostic Aphasia Examination).

Time frame
Baseline pre-intervention
4

Evaluation of changes in language abilities before and after rehabilitation - Clinical language assessment 1b

Assessment of oral expression (picture naming) with BDAE (Boston Diagnostic Aphasia Examination).

Time frame
Immediately after the first intervention; immediately after the second intervention

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University Hospital, Grenoble

Lead sponsor

Laboratoire de Psychologie et NeuroCognition

Collaborator

GIPSA-LAB

Collaborator

Source ClinicalTrials.gov
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