Sensory Synchronized Imaging and Neuromodulation

ConditionMajor Depressive Disorder

Trial statusNot yet recruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age18+

SponsorVA Office of Research and Development

About this trial

The purpose of this research study is to better understand the relationship between the type of brain stimulation used and how it changes brain activity in adult military Veterans. The goal is to use this understanding to develop new, personalized brain stimulation. The investigators evaluate brain changes from different types of transcranial magnetic brain stimulation (TMS).

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Men and women

English speaking

Military Veterans

Disqualifiers

Those with a contraindication for magnetic resonance imaging (MRIs), e.g. implanted metal

History of head trauma with loss of consciousness

History of seizures or on medications that substantially reduce seizure threshold

Neurological or uncontrolled medical disease

Trial design

Design model

Crossover

Treatments tested in this trial

TMS
Device
transcranial magnetic brain stimulation

Treatment groups

250 Participants

are divided into 2 treatment groups

Group A: Standard TMSActive comparator 1 intervention

Group B: Sensory-entrained TMS (seTMS)Active comparator 1 intervention

Trial outcomes

Primary outcomes

Transcranial Magnetic Stimulation (TMS) / Electroencephalography (EEG) change

Change in the TMS-EEG measure will be assessed before, during, and after each TMS session. Specifically, the difference in size of the evoked response after a single TMS pulse in the frontoparietal region will be quantified in microVolts and compared between standard TMS and sensory-entrained TMS (se-TMS).

Time frame

45 minutes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

VA Office of Research and Development

Lead sponsor

National Institute of Mental Health (NIMH)

Collaborator

Stanford University

Collaborator

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: