Sentence Production Training in Aphasia
ConditionAphasia
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age21-85
SponsorPurdue University
About this trial
This project focuses on developing a novel treatment for sentence production and comprehension in aphasia, using implicit priming. First set of experiments will aim examine which learning conditions are most effective in creating maximal training gains. Then, in a later study, the investigators will develop and test the efficacy of a novel treatment study based on findings from the first set of the studies.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Individuals with post-stroke aphasia
At least 6 months post-onset of eft hemisphere stroke
Native speaker of English
Normal or corrected to normal hearing and vision
Disqualifiers
Severe apraxia of speech
Other neurological conditions affecting communication (e.g., dementia)
Uncontrolled psychiatric/psychological conditions affecting thinking and communication
Active alcohol/substance abuse
Trial design
Design model
Single group
Treatments tested in this trial
Sentence training
BehavioralParticipants will be trained to read, make, and recall sentences during each session.
Treatment groups
104 Participants
are divided into 1 treatment groupGroup A: Structural priming trainingExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Production of target sentences on action description pictures
Production accuracy (percent correct)
Time frame
From baseline up to 1-week post training or 2-month post treatment2
Comprehension of target sentences in a sentence-to-picture matching task
Comprehension accuracy (percent correct)
Time frame
From baseline up to 1-week post training or 2-month post treatment3
Real-time comprehension of target sentences in a sentence-to-picture matching task
Changes in eye fixations to the target picture
Time frame
From baseline up to 1-week post training or 2-month post treatmentSecondary outcomes
1
Production of untrained sentences
Production accuracy (percent correct)
Time frame
From baseline up to 2-month post treatment2
Connected speech production - story retell
Increased production of complex utterances as measured by proportion of sentence-level utterances out of all utterances
Time frame
From baseline up to 2-month post treatment3
Connected speech production - picture description
Increased production of complex utterances as measured by proportion of sentence-level utterances out of all utterances
Time frame
From baseline up to 2-month post treatmentSponsors and contacts
Click on the lead sponsor to view all of their trials.
Purdue University
Lead sponsor
Temple University
Collaborator
University of California, San Diego
Collaborator
Source ClinicalTrials.gov