To learn how radiation treatment may affect your responses to vaccines against pneumonia.
Group 1A
Group 1B
Group 2A
Group 2B
Patients with compromised immunologic responses due to an uncontrolled intercurrent immunodeficiency (e.g., Human immunodeficiency virus (HIV), X-linked agammaglobulinemia) or previous or current immune suppressive therapy
Patients receiving intravenous immunoglobulin (IVIG) during the study or in the three months prior to study enrollment.
Patients with psychiatric illness/social situations that would limit compliance with study requirements.
Individuals with previous pneumococcal vaccination in the last 5 years.
MD Anderson Cancer Center will enroll 30 esophageal cancer patients. Massachusetts General Hospital in Boston, MA will enroll 30 HCC patients. MD Anderson Cancer Center \& Massachusetts General Hospital in Boston will jointly enroll up to 20 health volunteers.
Cohort
Prospective
Pneumonia vaccine
Biological/VaccineGiven by SC
Impact of grade IV radiation-induced lymphopenia on serologic responses to pneumococcal vaccination
Serologic responses will be calculated as the average fold change in antibody titer for each of 20 pneumococcal serotypes between baseline (time 0) and the first post-vaccination blood draw.
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