Serological Measurement of Montpellier Professionals' Contacts with Infectious Agents Responsible for Animal-borne Diseases

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity Hospital, Montpellier

About this trial

Zoonoses and arboviroses refer to a group of diseases transmitted from animals to humans, either directly or indirectly (via mosquitoes, ticks or contact with contaminated environments). Most of these diseases are found in certain tropical zones, but global warming and increased international trade are modifying their geographical distribution, with a gradual trend towards temperate regions. A number of these pathogens have already been detected in Occitania, including dengue fever, West Nile, leishmaniasis and Q fever. Given the region's high mosquito population and favorable climatic conditions, other zoonoses have a strong potential to appear in the region, or may already be circulating at a low level. The study focuses on 18 pathogens selected for their potential to emerge and establish themselves in the Occitanie region: Leishmaniasis, Leptospirosis, Brucellosis, Q fever, Rickettsiosis, Tularemia, Psittacosis, Lyme disease, Tick-borne encephalitis, Hantavirus, Hepatitis E virus, Dengue virus, Zika virus, Chikungunya virus, West-Nile virus, Usutu virus, Toscana virus, Crimean-Congo haemorrhagic fever virus.

The aim of the study is to find out whether patients have antibodies against these infectious agents, which would indicate that they have been exposed to them in the past, even in the absence of symptoms.

Describing the circulation of these pathogens will enable to implement appropriate public health measures to avoid the risk of epidemics (mosquito control, informing professionals, etc.), as well as to assess the risk incurred in the workplace and have this risk recognized by the healthcare system.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age 18 or over

Consultant in an infectious diseases department

Have given written consent to participate in the study

Working for the City or Metropolis of Montpellier in the Zoo, Espaces Vert or Ecolothèque departments.

Disqualifiers

- Pregnant and breast-feeding women

Persons benefiting from legal protection measures (guardianship, curatorship, safeguard of justice)

Participants who are not fluent in French and who do not have a support person capable of reading French.

Persons unable to express their consent.

Trial design

Design model

Single group

Treatments tested in this trial

  • Peripheral venous blood sample

    Other intervention

    Peripheral venous blood sampling for IgG serology against leishmaniasis, leptospirosis, brucellosis, Q fever, rickettsiosis, tularemia, psittacosis, Lyme disease, tick-borne encephalitis, hantavirus, hepatitis E virus, dengue virus, Zika virus, Chikungunya virus, West Nile virus, Usutu virus, Toscana virus, Crimean-Congo hemorrhagic fever virus.

Treatment groups

183 Participants
are divided into 1 treatment group
Group A: City of Montpellier employees working at the Zoo, the Ecolothèque and the Green Spaces DepartmentExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies). Leishmaniasis,

prevalence (in percentage) of pathogen IgG positivity against : Leishmaniasis,

Time frame
Baseline
2

Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies).Leptospirosis,

prevalence of pathogen IgG positivity against : Leptospirosis,

Time frame
Baseline
3

Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies).Brucellosis

prevalence of pathogen IgG positivity against : Brucellosis

Time frame
Baseline
4

Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies).Q fever

prevalence of pathogen IgG positivity against : Q fever

Time frame
Baseline

Secondary outcomes

1

Determine the factors associated with seropositivity to these diseases. socio-demographic criteria

OR of logistic regression of univariate model between serologies and socio-demographic criteria (age, sex, profession)

Time frame
Baseline
2

Determine the factors associated with seropositivity to these diseases. travel to endemic areas

OR of the logistic regression of the univariate model between serologies and travel to endemic areas for these diseases

Time frame
Baseline
3

Determine the factors associated with seropositivity to these diseases. occupational exposure

OR of the logistic regression of the univariate model between serologies and occupational exposure to these pathologies

Time frame
Baseline
4

Determine the factors associated with seropositivity to these diseases. exposure in private activities

OR of the logistic regression of the univariate model between serologies and exposure in private activities, including the importance of contact with transmission vectors,

Time frame
Baseline

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University Hospital, Montpellier

Lead sponsor

TransVIHMI UM, IRD UMI233, Inserm U1175

Collaborator

UMR 1058 Pathogenesis & Control of Chronic & Emerging Infections PCCEI

Collaborator

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