Serum Bicarbonate Changes During Laparoscopic Bariatric Surgery

ConditionAcid Base Disorder

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorIstinye University

About this trial

Pneumoperitoneum during laparoscopic bariatric surgery induces carbon dioxide absorption and may lead to perioperative alterations in acid-base balance. Serum bicarbonate (HCO₃-) plays a central role in metabolic compensation; however, the clinical relevance of perioperative bicarbonate changes remains insufficiently defined.

This prospective observational study aims to evaluate the association between pneumoperitoneum duration and perioperative serum bicarbonate change (ΔHCO₃-), and to investigate whether ΔHCO₃- is associated with early discharge readiness at 48 hours (DR-48) following laparoscopic bariatric surgery. Patients undergoing laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass will be enrolled consecutively. No alteration of routine clinical care will occur.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Adults aged ≥18 years

ASA physical status I-III

Scheduled for elective laparoscopic bariatric surgery (laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass)

Provided written informed consent

Disqualifiers

Age <18 years

ASA physical status IV or higher

Chronic obstructive pulmonary disease (COPD), asthma, or other severe chronic respiratory disease

Known chronic metabolic acidosis or renal failure

Trial population

Adult patients undergoing elective laparoscopic bariatric surgery (laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass) at a single tertiary care center. Participants will be enrolled consecutively and followed prospectively to assess perioperative serum bicarbonate changes and early discharge readiness without altering routine clinical management.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Laparoscopic Bariatric Surgery
Other intervention
Standard-of-care laparoscopic bariatric surgery (laparoscopic sleeve gastrectomy or Roux-en-Y gastric bypass) performed according to institutional protocols. No experimental intervention is introduced. The study prospectively observes perioperative serum bicarbonate changes and their association with pneumoperitoneum duration and early discharge readiness.

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

Perioperative Serum Bicarbonate Change (ΔHCO₃-)

Change in serum bicarbonate (HCO₃-) between the preoperative value (after induction, before pneumoperitoneum) and the postoperative 24-hour value, calculated as: ΔHCO₃- = HCO₃-(24 h postoperative) - HCO₃-(preoperative). The association between pneumoperitoneum duration (minutes) and ΔHCO₃- will be evaluated.

Time frame

From baseline (after induction, before pneumoperitoneum) to 24 hours postoperatively

Sponsors and contacts

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Istinye University

Lead sponsor

Source ClinicalTrials.gov

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