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Serum MicroRNAs as Diagnostic Biomarkers of Colorectal Cancer

ConditionsMicroRNAsColorectal CancermiR-15bmiR-21
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorBishoy Shehata

About this trial

evaluation the diagnostic value of certain MicroRNAs as biomarkers of Colorectal cancer by comparing its expression levels in Colorectal cancer patients and normal individuals.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Adults (age 18-75) diagnosed with primary CRC (histopathologically confirmed).

CRC patients who have not received prior treatment (i.e., chemotherapy or radiation).

Age-matched healthy controls without colorectal disease

Disqualifiers

Patients with secondary tumors or metastasis originating from non-colorectal sources.

Patients with prior history of CRC.

Patients who refuse to contribute in this study.

Trial population

Patients attending assiut university hospital

Trial design

Design model

Case-control

Time perspective

Cross-sectional

Treatments tested in this trial

  • certain serum MicroRNA biomarkers (miR-15b and miR-21)

    Diagnostic test

    miR-15b and miR-21 as diagnostic biomarkers of colorectal cancer

Treatment groups

80 Participants
are divided into 2 treatment groups
Group A: cases1 intervention
Group B: Control1 intervention

Trial outcomes

Primary outcomes

1

evaluation the diagnostic value of miRNAs as biomarkers of CRC by comparing its expression levels in CRC patients and normal individuals

use the results of measurement of certain serum miRNAs in persons with CRC and non-CRC individuals.

Time frame
baseline

Secondary outcomes

1

assessment the correlation between miRNAs expression levels and clinicopathological features such as tumor stage, grade, and metastasis

use the results of measurement of certain serum miRNAs in persons with CRC and non-CRC individuals.

Time frame
baseline
2

evaluation the sensitivity, specificity, and diagnostic accuracy of miRNAs as standalone biomarkers

use the results of measurement of certain serum miRNAs in persons with CRC and non-CRC individuals.

Time frame
baseline

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Bishoy Shehata

Lead sponsor

Assiut University

Sponsor institution

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: