This study aims to evaluate the relationship between serum myostatin and irisin levels and bone mineral density and muscle strength in postmenopausal women. Participants will be grouped according to bone mineral density as normal, osteopenic, or osteoporotic. Serum myostatin and irisin levels will be measured, and muscle strength will be assessed using handgrip strength and the five times sit-to-stand test. The associations between biochemical and functional parameters will be analyzed.
Postmenopausal women aged between 50 and 65 years Availability of bone mineral density measurement by dual-energy X-ray absorptiometry (DEXA) Willingness to participate in the study
Presence of malignancy Chronic kidney disease Chronic liver disease Neuromuscular disorders Recent major surgery or trauma Use of medications affecting bone or muscle metabolism
The study population will consist of postmenopausal women aged between 50 and 65 years who attend the outpatient clinic and meet the inclusion criteria. Participants will be classified into normal, osteopenic, and osteoporotic groups based on bone mineral density measurements obtained by dual-energy X-ray absorptiometry (DEXA).
Case-only
Cross-sectional
Not listed
Relationship between serum myostatin and irisin levels and bone mineral density (T-score)
Serum myostatin and irisin levels will be measured from fasting venous blood samples, and bone mineral density will be assessed using dual-energy X-ray absorptiometry (DEXA). The relationship between these parameters will be evaluated.
Relationship between serum myostatin and irisin levels and muscle strength
Muscle strength will be assessed using handgrip strength, and its relationship with serum myostatin and irisin levels will be evaluated.
Comparison of serum myostatin and irisin levels among bone mineral density groups
Serum myostatin and irisin levels will be compared among normal, osteopenic, and osteoporotic groups defined by dual-energy X-ray absorptiometry (DEXA).
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Kanuni Sultan Suleyman Training and Research Hospital
Lead sponsor
Saglik Bilimleri Universitesi
Collaborator
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