Sevoflurane General Anesthetic and Spatial Memory in Humans
ConditionSpatial Memory Disorder
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age30-50
SponsorUniversity of Chile
About this trial
The goal of this observational study is to learn about the effect of general anesthetic on spatial memory in adults who will undergo to an elective surgery. The main question it aims to answer is:
• A surgical event under general anesthesia with sevoflurane transiently impairs spatial memory in humans and induces an increase in inflammatory cytokines.
Participants will perform a virtual maze test and plasma samples will be taken before and after surgery.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Candidate for elective laparoscopic surgery of cholecystectomy.
Age 30 to 50 years.
Disqualifiers
Visual or hearing difficulties.
Malignant hyperthermia.
Being treated with centrally acting drugs, such as anxiolytics, antidepressants, antipsychotics, anticonvulsants, anticholinergics, and first-generation antihistamines.
Present a disorder of the sphere of neuropsychiatry
Trial population
Adult patients bewteen 30 and 50 years old who will undergo to an elective laparoscopic surgery of cholecystectomy.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Surgery/general anesthesia
Procedure/SurgeryAdult patients between the ages of 30 and 50 who are to undergo elective surgery under general anesthesia will have their spatial memory tested and interleukin 1beta and alpha tumor necrosis measured before and after surgery.
Treatment groups
22 Participants
are divided into 1 treatment groupGroup A: Adults 30-50 years1 intervention
Trial outcomes
Primary outcomes
1
Virtual spatial memory
Time to reach the goal
Time frame
1th day after surgerySecondary outcomes
1
Interleukin-1beta
Interleukin-1beta plasma concentration
Time frame
1st day after surgery2
Interleukin-1beta
Interleukin-1beta plasma concentration
Time frame
7th day after surgery3
Interleukin-1beta
Interleukin-1beta plasma concentration
Time frame
30th day after surgery4
Tumor necrosis factor alpha
Tumor necrosis factor alpha plasma concentration
Time frame
1st day after surgerySponsors and contacts
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Source ClinicalTrials.gov