Health TrialsbyHealthPanel

Sex Differences in E-Cigarette Perception

ConditionsNicotine DependenceE-cigarette Use
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age21-44
SponsorYale University

About this trial

This study examines differences between males and females in the appeal and addiction potential of menthol flavored e-cigarettes with and without nicotine.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Able to read/write in English

Current cigarette smoking

Prior e-cigarette exposure

Biochemically verified cigarette use

Disqualifiers

Significant medical concerns that would increase study risk

Use of psychoactive drugs unless prescribed and stable

Allergy to menthol or other e-liquid ingredients

Dislike of menthol

Trial design

Design model

Crossover

Treatments tested in this trial

  • Nicotine Level 1 (0mg/ml)

    Other intervention

    Menthol with be paired with 0mg/ml nicotine in an e-cigarette

  • Nicotine Level 2 (36mg/ml)

    Other intervention

    Menthol with be paired with 36mg/ml nicotine in an e-cigarette

  • Nicotine Level 3 (59mg/ml)

    Other intervention

    Menthol with be paired with 59mg/ml nicotine in an e-cigarette

Treatment groups

60 Participants
are divided into 2 treatment groups
Group A: Sampling Session - Lab 1Experimental treatment 3 interventions
Group B: Concurrent Choice Session- Lab 2Experimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

Proportion of Choices

Differences in proportion of choices for the two menthol e-cigarette for males and females in the Lab 2 preference task

Time frame
For the 3 hour period of the Lab 2 preference task
2

Breakpoint

Difference in highest point of the progressive ratio schedule obtained between males and females

Time frame
During the 3 hour period of the Lab 2 preference task

Secondary outcomes

1

Reward

Difference in scores (range: 0-100) of the Liking/Wanting Subscale of the Drug Effects Questionnaire

Time frame
Immediately (~2 minutes) after e-cigarette exposures in Lab 1

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Yale University

Lead sponsor

National Institute on Drug Abuse (NIDA)

Collaborator

Source ClinicalTrials.gov
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