Sex Differences in Exercise-Induced Hypoalgesia
ConditionHealthy Adult
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorCentro Universitario La Salle
About this trial
Exercise-induced hypoalgesia (EIH) refers to the reduction in pain sensitivity following acute exercise. Although aerobic exercise has been shown to induce hypoalgesia in healthy individuals, it remains unclear whether the magnitude of this response differs between men and women.
This quasi-experimental study aims to evaluate sex differences in pressure pain thresholds following a standardized aerobic exercise protocol using a lower-limb cycle ergometer. Pressure pain thresholds will be assessed before exercise, immediately after exercise, and 30 minutes after exercise in healthy adults aged 18 to 65 years.
The findings of this study may contribute to improving individualized exercise prescription strategies based on sex differences in pain modulation.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Healthy male and female adults
Age between 18 and 65 years
Able to perform moderate-to-vigorous aerobic exercise
Able to understand study procedures
Disqualifiers
Cardiovascular, respiratory, neurological, or metabolic diseases contraindicating exercise
Current musculoskeletal pain or injury
Analgesic medication use within 24 hours prior to testing
Vigorous exercise within 24 hours prior to testing
Trial design
Design model
Parallel
Treatments tested in this trial
Aerobic exercise using cycle ergometer
BehavioralParticipants will perform a 30-minute aerobic exercise protocol using a lower-limb cycle ergometer at 70% heart rate reserve. The protocol includes: * 5-minute warm-up * 20-minute exercise at target intensity * 5-minute cool-down Heart rate will be monitored continuously using a validated heart rate monitor.
Treatment groups
30 Participants
are divided into 2 treatment groupsGroup A: Male participantsExperimental treatment 1 intervention
Group B: Female participantsExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Pressure Pain Threshold at Quadriceps
Pressure pain threshold measured using a digital pressure algometer at the quadriceps muscle.
Time frame
Pre-exercise, immediately post-exercise, and 30 minutes post-exerciseSecondary outcomes
1
Pressure Pain Threshold at Lateral Epicondyle
Pressure pain threshold measured at a remote anatomical site using pressure algometry.
Time frame
Pre-exercise, immediately post-exercise, and 30 minutes post-exerciseSponsors and contacts
Click on the lead sponsor to view all of their trials.
Centro Universitario La Salle
Lead sponsor
Universidad Rey Juan Carlos
Collaborator
Source ClinicalTrials.gov
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