Sex Hormones and Aging
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age50-70
SponsorUniversity of Michigan
About this trial
This study investigates the influence of sex hormones and exercise on age-related neuromuscular decline in females. Specifically, the research aims to evaluate how hormonal variations impact both age-associated neuromuscular decline and the subsequent adaptations to exercise and resistance training.
Age-related declines in neuromuscular function are especially pronounced in females, potentially due to the sharp drop in estradiol after menopause. This project will compare postmenopausal females who have not taken hormonal therapy (HT) to age-matched females taking HT.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
None
Disqualifiers
Females who are pregnant or likely to be pregnant. Female subjects of childbearing age will be asked of the possibility of pregnancy and will be excluded from the study if they are pregnant or become pregnant during the study.
Females who are not currently taking HT but have taken HT in the past 5 years.
Severe obesity (body mass index, BMI, > 45 kg/m2): this will be calculated from measured height and weight
Untreated hypothyroidism
Trial design
Design model
Parallel
Treatments tested in this trial
HRT: High-Resistance Strength Training
Other interventionEach participant will attend 2 sessions per week for 8 weeks. A training session will start with a 10-minute full body dynamic warm-up (e.g., bodyweight movements and mobility exercises). The participant will then perform bilateral lower body high-resistance strength training exercises (leg extension and leg press) for 4 sets of 8-10 repetitions.
Control: High-Resistance Strength Training
Other interventionEach participant will attend 2 sessions per week for 8 weeks. A training session will start with a 10-minute full body dynamic warm-up (e.g., bodyweight movements and mobility exercises). The participant will then perform bilateral lower body high-resistance strength training exercises (leg extension and leg press) for 4 sets of 8-10 repetitions.
Treatment groups
120 Participants
are divided into 2 treatment groupsGroup A: Postmenopausal Hormone TherapyExperimental treatment 1 intervention
Group B: Postmenopausal Female ControlsExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Strength - Maximal Voluntary Contraction (MVC)
Changes in MVC after 8 weeks resistance training. MVC is the greatest force generated during a brief isometric contraction.
Time frame
One session before and then after 8 weeks of training2
Fatigability - Reduction in Power
Reduction in limb power and maximal force in response to a dynamic fatiguing contraction.
Time frame
One session before and then after 8 weeks of training3
Strength - 1 Repetition Maximum
Reduction in limb power and maximal force in response to a dynamic fatiguing contraction
Time frame
One session before and then after 8 weeks of trainingSponsors and contacts
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Source ClinicalTrials.gov