Short-term Fat Overfeeding on the Effects of Liver Metabolism
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorUniversity of Oxford
About this trial
Despite work showing the overconsumption of saturated fatty acids (SFA) to be metabolically deleterious, debate continues about whether there is a link between SFA and cardiovascular disease risk. To explore this, we are undertaking a human in vivo parallel-design study, comparing two isocaloric high-fat diets; one enriched with SFA and the other enriched with unsaturated fatty acids (UFAs), to determine the impact of dietary fat composition on postprandial metabolism, liver fat, cardiac fat and cardiac function.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
The participant is willing and able to give informed consent for participation in the study.
Male or Female, aged ≥18 or ≤65 years.
Body Mass Index ≥19 ≤35 kg/m2
No medical condition or relevant drug therapy that is known to affect liver or adipose tissue metabolism.
Disqualifiers
The participant is unwilling or unable to give informed consent for participation in the study. - Aged ≤18 or ≥65 years
Body Mass Index ≤19 or ≥35kg/m2
Blood haemoglobin <135mg/dL for men and <120mg/dL for women
Donated (or lost) ≥250 ml of blood in the previous two months.
Trial design
Design model
Parallel
Treatments tested in this trial
Diet
BehavioralHigh fat (\~60% of total energy intake) diet enriched with either SFA or UFA
Treatment groups
26 Participants
are divided into 2 treatment groupsGroup A: High fat, high SFAExperimental treatment 1 intervention
Group B: High fat, high UFAExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Liver fat
Changes in intrahepatic triglyceride, as measured by MRI
Time frame
Pre- and after approx 28 days of consuming interventional dietSecondary outcomes
1
Postprandial plasma biochemistry
Changes in postprandial plasma triglycerides, glucose, insulin over 6 hours following consumption of a standardized experimental test meal
Time frame
Pre- and after approx 28 days of consuming interventional dietSponsors and contacts
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Source ClinicalTrials.gov