Bronchiolitis obliterans (BO) is the well-known manifestation of the chronic pulmonary graft-versus-host disease(GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). The pathophysiology of BO is, however, poorly known. The available data strongly support the role of respiratory viruses, in particular paramyxoviruses (parainfluenzae virus (PIV), respiratory syncytial virus, metapneumovirus). It is likely that the alloimmune response triggered by the respiratory virus is inadequate and leads to the peribronchiolar fibrotic process. The objective is to analyze the kinetics of profiles of the blood and respiratory host responses resulting from a high or low parainfluenza respiratory infection, in order to evaluate if the occurrence of a BO is associated with a specific signature We will evaluate the predictive signature of a BO after a parainfluenza virus infection by characterizing the differences between the patients evolving and those not evolving to a BO at 2 months after the infection.
Adults having received a hematopoietic stem cell transplantation for less than two years
Availability of respiratory function tests prior to infection
Presence of PIV respiratory infection documented by identification of the virus by PCR in the upper and/or lower respiratory tract
Symptoms of respiratory infection ≤ 5 days
Presence of a respiratory virus infection other than PIV
Viral respiratory co-infections
Bacterial or fungal respiratory infections
Treatment with ribavirin, oseltamivir or any other antiviral with activity against respiratory viruses
Adult recipients of allogeneic HSCT with PIV pulmonary infection
Case-control
Prospective
samples
Other interventionblood sample nasal swab
Host response in both blood and respiratory tract after PIV infection
Identify the cellular signaling pathways associated with the development of BO following parainfluenzae virus infection
Evaluate differences in transcriptomic profiles between blood and respiratory tract
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