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Skeletal Muscle Myokine Response to Acute Eccentric Exercise

ConditionSkeletal Muscle
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-35
SponsorUniversity of Manitoba

About this trial

The purpose of this study is to evaluate the acute local skeletal muscle inflammatory response to thigh muscle (quadriceps) eccentric muscle actions. Eccentric muscle actions occur when the muscle is lengthening as it contracts. This is a pilot project to assess the degree of inflammatory biomarkers, called myokines, that are released locally in skeletal muscle tissue after an acute bout of resistance-exercise using a resistance-exercise machine called an isokinetic dynamometer.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

18-35 years old

healthy

recreationally active (>/= 150 minutes of moderate to vigorous physical activity per week for at least the past three months)

Disqualifiers

"yes" answer to the Get Active Questionnaire which screens for health conditions that may affect exercise ability

Trial design

Design model

Single group

Treatments tested in this trial

  • Eccentric resistance-exercise

    Procedure/Surgery

    Each participant will complete 300 repetitions of eccentric knee extensions using an isokinetic dynamometer after a baseline skeletal muscle biopsy is taken. Three hours following this, a second muscle biopsy will be taken to evaluate the changes in the dependent variables being measured (myokines).

Treatment groups

12 Participants
are divided into 1 treatment group
Group A: Eccentric ExerciseExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Apelin

Concentration of apelin in skeletal muscle tissue

Time frame
Baseline and 3-hours post-exercise
2

Fibroblast growth factor-21

Concentration of fibroblast growth factor-21 in skeletal muscle tissue

Time frame
Baseline and 3-hours post-exercise
3

Irisin

Concentration of irisin in skeletal muscle tissue

Time frame
Baseline and 3-hours post-exercise
4

Interleukin-6

Concentration of interleukin-6 in skeletal muscle tissue

Time frame
Baseline and 3-hours post-exercise

Secondary outcomes

1

Body mass

Body mass in kilograms

Time frame
Baseline
2

Body height

Body height in meters

Time frame
Baseline
3

Body mass index

Body mass index in kg/m\^2

Time frame
Baseline
4

Fat mass

Fat mass in kilograms

Time frame
Baseline

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Manitoba

Lead sponsor

Source ClinicalTrials.gov
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