Skin Wetting in Burn Survivors
ConditionBurn Injury
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorUniversity of Texas Southwestern Medical Center
About this trial
This project will identify the efficacy of whole body skin wetting aimed to attenuate excessive elevations in internal body temperatures during physical activity in well-healed burn survivors. The investigators will conduct a randomized crossover design study. Non-burned control subjects, subjects who experienced burns covering \~20% to 40% of their body surface area, and subject having burns \>40% of their body surface area will be investigated. Subjects will exercise in heated environmental conditions while receiving no cooling or whole body skin wetting.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Healthy male and female subjects
18-65 years of age.
Free of any underlying medical conditions
Disqualifiers
Any burn-related injuries resulting in at least one night of hospitalization.
Heart disease or any other chronic medical condition requiring regular medical therapy including cancer, diabetes, and hypertension.
Abnormalities detected on routine screening
Individuals who participate in a structured aerobic exercise training program at moderate to high intensities.
Trial design
Design model
Crossover
Treatments tested in this trial
Whole body cooling
Other interventionSubjects will exercise for 60 minutes in the indicated environmental condition while being exposed to whole body skin wetting. Skin wetting will be performed by spraying water onto the whole body throughout the exercise bout.
Non-cooling
Other interventionSubjects will exercise for 60 minutes in the indicated environmental condition while being exposed to no cooling modalities.
Treatment groups
40 Participants
are divided into 2 treatment groupsGroup A: Hot and Dry Environment_no coolingExperimental treatment 1 intervention
Group B: Hot and Dry Environment_whole body skin wettingExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Core Temperature
During exercise, one's core body temperature will increase. This device will measure this increase in core body temperature throughout the exercise.
Time frame
Prior to and throughout the bout of exercise; an average of 90 minutes.Secondary outcomes
1
Mean Skin Temperature
Average skin temperature from six sites.
Time frame
Prior to and throughout the bout of exercise; an average of 90 minutes.2
Rate Pressure Product
Obtained from heart rate and systolic blood pressure.
Time frame
Prior to and throughout the bout of exercise; an average of 90 minutes.3
Whole body sweat rate
Whole body sweat rate will be measured from pre and post nude body mass measures.
Time frame
Before and after exercise. 2 min per measure.Sponsors and contacts
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Source ClinicalTrials.gov