Sleep and Rehearsal-Driven Memory in Epilepsy
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorHospices Civils de Lyon
About this trial
Memory consolidation transforms unstable memory traces into lasting representations, a process enhanced by both sleep and rehearsal during learning. Rehearsal is thought to accelerate consolidation by inducing memory reactivations that resemble those occurring during sleep. However, the respective mechanisms of sleep- and rehearsal-induced consolidation-and their potential interactions-remain poorly understood, especially in patients with temporal lobe epilepsy, where rehearsal might help compensate for memory deficits linked to hippocampal dysfunction, and where sleep may exacerbate epileptic activity. The CORESOM-EPI study aims to compare the effects of rehearsal and sleep on memory consolidation in patients undergoing video-EEG monitoring. Participants will learn "object-place" associations under two conditions (single versus repeated encoding), with memory tested immediately and again after a 12-hour delay. This delay will either include a full day awake or a night of sleep, allowing direct comparison of sleep- and rehearsal-related consolidation effects. Each participant will perform the task twice, with "wake" and "sleep" condition, in a balanced order. As a preliminary phase of the CRIMES study (ANR-DFG 2024), CORESOM-EPI will help assess how sleep and rehearsal influence memory consolidation in epilepsy. It will also serve to adapt the behavioral task for clinical use, paving the way for a future intracranial EEG investigations that will explore the neural networks involved and their modulation by epileptic activity.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patient with epilepsy (any type of epilepsy)
Hospitalized for video-EEG recording lasting at least 4 days
Aged 18-65 years
Disqualifiers
Major cognitive impairment other than memory deficit
Refusal to participate
Pregnant women, women in labor or nursing mothers
Persons deprived of their liberty by judicial or administrative decision
Trial population
Patients with epilepsy admitted to the Functional Neurology and Epileptology Department of the Hospices Civils de Lyon (University Hospital) for video-EEG monitoring will be invited by the investigating physician to participate in the study. If patients wish to take part, they will be asked to perform a cognitive task.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Cognitive memory task on a computer
Other interventionEncoding: (1) Participants will learn 60 associations between pairs of items (cue and target) that are presented sequentially at unique locations on a screen, in a given context. 30 pairs are presented once, and 30 pairs are presented repeatedly (4 times). (2) After learning, the first recall phase begins after a short delay of 30 minutes: 50% of the pairs are tested in a similar way, this time with an assessment of contextual memory. (3) The remaining 50% of pairs are tested after a 12-hour delay, involving either a day awake (condition 1) or a night asleep (condition 2).
Eye tracking
Other interventionEye-tracking will be carried out during the task to ensure that participants are focused on the task (quantification of the number and duration of eye fixations in the area of interest corresponding to the target presentation)
Questionnaires on task-related fatigue
Other interventionQuestionnaire on task-related fatigue (Likert-scale) will be completed by participants between blocks of items during the task
Questionnaire on task difficulty
Other interventionQuestionnaires on task difficulty (Likert-scale) will be completed by participants at the end of the task
Karolinska scale
Other interventionParticipants' state of sleepiness will be assessed at the beginning of each stage (encoding, immediate recall, delayed recall) using the Karolinska sleepiness scale
Treatment groups
20 Participants
are divided into 2 treatment groupsGroup A: WAKE - SLEEP5 interventions
Group B: SLEEP-WAKE5 interventions
Trial outcomes
Primary outcomes
1
Change in the percentage of object categories recalled (vs. not recalled) between immediate (30 min after learning) and delayed (12h after learning) recall for rehearsed versus non-rehearsed items.
The impact of rehearsal on object category recognition in an object-place learning paradigm is assessed. For the primary outcome, data from the 2 conditions ("wake" and "sleep" during the 12h period between immediate and delayed recall) will be pooled. Each participant will take part in the wake and sleep condition over 4 days (2 conditions separated by at least 24h), in a balanced order between participants.
Time frame
Day 22
Change in the percentage of object categories recalled (vs. not recalled) between immediate (30 min after learning) and delayed (12h after learning) recall for rehearsed versus non-rehearsed items.
The impact of rehearsal on object category recognition in an object-place learning paradigm is assessed. For the primary outcome, data from the 2 conditions ("wake" and "sleep" during the 12h period between immediate and delayed recall) will be pooled. Each participant will take part in the wake and sleep condition over 4 days (2 conditions separated by at least 24h), in a balanced order between participants.
Time frame
Day 2 + 12 hours3
Change in the percentage of object categories recalled (vs. not recalled) between immediate (30 min after learning) and delayed (12h after learning) recall for rehearsed versus non-rehearsed items.
The impact of rehearsal on object category recognition in an object-place learning paradigm is assessed. For the primary outcome, data from the 2 conditions ("wake" and "sleep" during the 12h period between immediate and delayed recall) will be pooled. Each participant will take part in the wake and sleep condition over 4 days (2 conditions separated by at least 24h), in a balanced order between participants.
Time frame
Day 2 + 36 hours4
Change in the percentage of object categories recalled (vs. not recalled) between immediate (30 min after learning) and delayed (12h after learning) recall for rehearsed versus non-rehearsed items.
The impact of rehearsal on object category recognition in an object-place learning paradigm is assessed. For the primary outcome, data from the 2 conditions ("wake" and "sleep" during the 12h period between immediate and delayed recall) will be pooled. Each participant will take part in the wake and sleep condition over 4 days (2 conditions separated by at least 24h), in a balanced order between participants.
Time frame
Day 2 + 48 hoursSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov