Sleep-disordered Breathing After Solid Organ Transplantation

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversitaire Ziekenhuizen KU Leuven

About this trial

Sleep-disordered breathing (SDB) describes a group of disorders in which partial or complete cessation of breathing occurs many times throughout the night, resulting in daytime sleepiness or fatigue that interferes with a person's ability to function and reduces quality of life. Transplantation has become an important treatment modality for end-stage organ failure. Transplant recipients are now living longer and, hence, develop chronic adverse medical conditions. Furthermore, transplantation is associated with weight gain. Despite the high prevalence of poor sleep and cardiovascular conditions among transplant patients, SDB is not well studied in these patients.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients 1 year after lung transplantation

Disqualifiers

Refusal of PSG

Medical contra-indication to perform PSG

Trial population

Patients 1 year after lung transplantation are systematically evaluated by polysomnography.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • No intervention - Diagnostic polysomnography at 1 year after lung transplantation

    Other intervention

Treatment groups

300 Participants
are divided into 1 treatment group
Group A: SDB and lung transplantation1 intervention

Trial outcomes

Primary outcomes

1

Number of participants with SDB and type (central or obstructive) of SDB

Prevalence of different types of SDB after lung transplantation

Time frame
1 year after lung transplantation

Secondary outcomes

1

Echocardiography

Correlations between SDB and heart function

Time frame
1 year after lung transplantation
2

Lung function measurement

Correlations between SDB and lung function

Time frame
1 year after lung transplantation
3

Blood analysis

Correlations between SDB and renal function

Time frame
1 year after lung transplantation
4

24h blood pressure

Evaluation of relationship between hypertension and SDB

Time frame
1 year after lung transplantation

Other outcomes

Sponsors and contacts

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