Health TrialsbyHealthPanel

Sleep, Light, Circadian, Central Oxidative Stress

ConditionsNon-visual Effects of LightChronic Variable Sleep Deficiency
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-40
SponsorBeth Israel Deaconess Medical Center

About this trial

Irregular sleep timing and sleep deficiency are pervasive in society despite evidence that sleep deficiency impairs cognition and is linked to neurodegenerative disease. Potential pathways underlying the adverse cognitive function and brain health associated with irregular insufficient sleep include misalignment of sleep from the internal \~24-hour body clock and brain oxidative stress. This research will investigate these putative pathways and inform future interventions to mitigate the impact of sleep loss on cognition and brain health.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Healthy participants 18-40 years old.

Disqualifiers

Volunteers must be drug-free (including caffeine, nicotine, and alcohol) for the entire duration of the study, with no history of drug or alcohol dependency.

Subjects must be free from any significant impairments of the visual system, including color blindness.

Subjects must be ambulatory, have no major visual or auditory handicaps, and be free from any major acute, chronic or debilitating medical conditions.

history of psychiatric illnesses or psychiatric disorders

Trial design

Design model

Parallel

Treatments tested in this trial

  • Chronic Variable Sleep Deficiency

    Behavioral

    Repeated cycles of sleep restriction followed by recovery sleep.

  • Sleep- and Circadian-Informed Lighting

    Behavioral

    Ambient visible light exposure with modulated intensity and spectrum

  • Dim Light

    Behavioral

    \<3 lux dim ambient lighting while awake

  • Room light

    Behavioral

    \~90 lux ambient lighting while awake

  • Control sleep

    Behavioral

    Nightly 8-h sleep opportunity

Treatment groups

40 Participants
are divided into 4 treatment groups
Group A: Dim light controlExperimental treatment 2 interventions
Group B: Dim-light CVSDExperimental treatment 2 interventions
Group C: Room-light CVSDExperimental treatment 2 interventions
Group D: SCIL CVSDExperimental treatment 2 interventions

Trial outcomes

Primary outcomes

1

circadian phase shifts in melatonin sulfate rhythm

Time frame
Baseline: Day 1 of study, Final: Day 8 of study
2

Accuracy on the matrix reasoning task

Time frame
Daily over 8 days throughout study intervention
3

WASO on the PSG

Time frame
Baseline sleep, first short sleep, second short sleep.
4

MRS-derived GSH in the mPFC

Time frame
Baseline: Day 1 of study, Final: Day 8 of study

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Beth Israel Deaconess Medical Center

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: