Sleep to Predict Recovery In Unconscious Patients With Acute Brain Injury

P-value for prediction of the detection of cognitive motor dissociation (CMD)

P-value for separating move vs non-move instructions on power spectral density data using a support vector machine learning algorithm.

Prediction of recovery of consciousness by day 28 after brain injury

Recovery of consciousness will be determined using the Coma Recovery Scale-Revised Scale (CRS-R) indexing consciousness as either minimally conscious state-plus (MCS-plus: the presence of signs of conscious awareness that include responses to commands or intelligible verbal output) or emergence from a minimally conscious state (EMCS: the return of the ability to use common objects in a functional manner or correctly respond to basic yes-or-no questions about situational orientation). Both would qualify as recovery of consciousness. The CRS-R full score ranges from 0 to 23, with higher scores representing higher levels of consciousness.

Sleep as a prognosticator of long-term independence and disability after traumatic brain injury (TBI)

This outcome will be assessed using the Glasgow Outcome Scale-Extended (GOS-E) Scale, which is an 8-level standardized clinical scale used to measure functional recovery and independence after a brain injury. Higher GOS-E scores indicate a better recovery, higher functional independence, and a greater return to normal daily activities. GOS-E score of ≥4 by 12-month post injury will serve as the primary measure to define independence indicating that the participant can be left alone at home for at least 8 hours in a day.

Sleep as a prognosticator of long-term disability after intracerebral hemorrhage (ICH)

This outcome will be assessed using the Modified Rankin Scale (mRS). The full score ranges from 0 to 6, measuring the degree of disability or dependence in daily activities. Higher scores mean greater disability and dependence, whereas lower scores mean better recovery and independence. Recovery from disability will be set at a score of 3 or below by 12 months post injury, indicating no more than moderate disability, where a person requires some help with daily activities but is still able to walk without assistance.

Recovery of consciousness (CRS-R score ≥ 8)

Number of participants who have a Coma Recovery Scale-Revised (CRS-R) score of 8 or above.

Recovery of consciousness (CRS-R score = 10)

Number of participants who have a Coma Recovery Scale-Revised (CRS-R) score of 10.

Recovery of consciousness

Presence of subtle clinical signs of consciousness

Recovery of consciousness using the CRSR-FAST

Coma Recovery Scale-Revised For Accelerated Standardized Testing (CRSR-FAST) score does not use a numerical scoring range like the full-length test; instead, it results in a binary rating of "conscious" or "not conscious." If at least one of the five core behaviors are present, the participant is considered conscious.