Small Nerve Fiber Activity in Patients with Carpal Tunnel Syndrome Assessed Via Quantitative Sensory Testing

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-65
SponsorBrooke Army Medical Center

About this trial

The diagnosis of carpal tunnel syndrome (CTS) is typically based on clinical findings and confirmatory electrodiagnostic testing. However, electrodiagnostic testing can only assess large A-alpha and A-beta nerve fibers. Quantitative sensory testing (QST) is a series of tests used to assess small nerve fiber changes in the A-delta, c-fibers, and A-beta nerve fibers as well. Previous studies have used QST to assess small nerve fiber changes related to carpal tunnel syndrome and found changes compared to controls. This study will utilize a course of standard physical therapy care and assess for any changes to small nerve fiber activity and how those changes may or may not relate to patient outcomes.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial design

Design model

Single group

Treatments tested in this trial

  • Physical Therapy

    Other intervention

    The intervention will be physical therapy standard care.

Treatment groups

48 Participants
are divided into 1 treatment group
Group A: Carpal Tunnel SyndromeExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Quantitative Sensory Testing (QST)

QST is a test method that measures sensory thresholds for temperature sensations, touch, vibration, and pain and is described in section 10.1. All thermal testing (CDT, WDT, CPT, and HPT) will be performed via the TSA 2 Thermosensory Stimulator.

Time frame
From enrollment until the end of the study at 12 weeks

Secondary outcomes

1

Boston Carpal Tunnel Questionnaire (BCTQ)

The BCTQ is a self-based outcome scale measured with 2-parts, the symptom severity scale and functional status scale. Both scales are likert scales 1-5.

Time frame
From enrollment until the end of the study at 12 weeks
2

Numeric Pain Rating Scale (NPRS)

he NPRS is an 11-point scale ('0' indicating no pain, and '10' worst imaginable pain) that will be used to assess pain intensity. This will be measured as the mean of three pain ratings: best pain rating over 24 hours, worst pain rating over 24 hours, and current pain rating.

Time frame
From enrollment until the end of the study at 12 weeks

Other outcomes

Sponsors and contacts

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