Health TrialsbyHealthPanel

Snacking Effects on the Brain Response to Foods and Satiety During Dieting

ConditionOverweight/Obesity
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age25-45
SponsorUniversity of Colorado, Denver

About this trial

This study plans to learn more about how different types of snacks may affect brain processes relating to eating behaviors during a diet intervention.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

25-45 years old

BMI at least 27 kg/m2

Comfortable completing a weight-loss intervention\

Willing to consume a daily snack of either walnuts or pretzels

Disqualifiers

Nut or wheat allergy

History of bariatric surgery

Current eating disorder

Current illicit substance use

Trial design

Design model

Parallel

Treatments tested in this trial

  • Snack Type 1: Walnuts

    Other intervention

    Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 1 group will be asked to eat a daily snack of walnuts, which will be provided by the study team.

  • Snack Type 2: Pretzels

    Other intervention

    Participants will complete a 12 week diet intervention, during which they will be asked to reduce their daily caloric intake. During the diet intervention, participants in the Snack Type 2 group will be asked to eat a daily snack of pretzels, which will be provided by the study team.

Treatment groups

70 Participants
are divided into 2 treatment groups
Group A: Snack Type 1: WalnutsExperimental treatment 1 intervention
Group B: Snack Type 2: PretzelsActive comparator 1 intervention

Trial outcomes

Primary outcomes

1

Percent change in Blood Oxygen Level Dependent (BOLD) response to visual food cues as measured by functional magnetic resonance imaging

Percent change in blood oxygen level dependent (BOLD) response from baseline to after the 12-week intervention while viewing visual food cues will be measured using functional magnetic resonance imaging (fMRI), focusing on insula, striatum, amygdala, and prefrontal cortex.

Time frame
Baseline, 12 weeks

Secondary outcomes

1

Change in percent body fat

Change in percent body fat from baseline to after the 12-week intervention.

Time frame
Baseline, 12 weeks
2

Change in appetite response to a meal

Change in appetite response to a meal (area under the curve for visual analog scale \[VAS\] ratings of hunger and satiety across fasted and fed states) from baseline to after the 12-week intervention.

Time frame
Baseline, 12 weeks
3

Change in food cravings

Change in food cravings (using the Food Cravings Questionnaire) from baseline to after the 12-week intervention

Time frame
Baseline, 12 weeks
4

Change in dietary restraint

Change in dietary restraint (measured using the dietary restraint subscale of the Three Factor Eating Questionnaire) from baseline to after the 12-week intervention.

Time frame
Baseline, 12 weeks

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Colorado, Denver

Lead sponsor

California Walnut Commission

Collaborator

Source ClinicalTrials.gov
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