About this trial
Lubrication gels are widely used in numerous gynecologic procedures in order to ease the insertion of speculum and visualize the cervix. It was shown that applying lubricating gels significantly decreases patient pain during vaginal speculum examination. While many fertility specialists use lubrication gels to insert the speculum during embryo transfer (ET), others are strongly reluctant to use gels due to concern that they might have a detrimental effect on embryos and ET success. Similar concern was prevalent regarding the use of lubrication gel during Pap-smear for detection of cervical dysplasia. However, several studies have shown that the use of small amount of water-soluble gel does not change cervical cytology. Lubrication gels might have deleterious effect on sperm motility. However, there wasn't any study examining the effect of lubricant gel on ET success.
The investigators hypothesize that using a lubrication gel will not reduce the live birth rate per transfer, but decrease patient pain during procedure.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age 18-40
Fresh and thawed ET
Patients undergoing their 1st-3rd ET
ET of 1-2 embryos
Disqualifiers
Age>40
Egg donation cycles
Trial design
Parallel
Treatments tested in this trial
Sterile water-based gel
Other interventionInsertion of the speculum during ET will be performed using 5 gr of water-based, sterile gel
Treatment groups
Trial outcomes
Primary outcomes
Ongoing pregnancy or live birth rate.
Number of patients with ongoing pregnancy or live birth at \>20 week's gestation.
Secondary outcomes
Positive serum BHCG
Number of patients with positive serum BHCG test.
Clinical pregnancy
Number of patients with transvaginal ultrasound test demonstrating fetal cardiac activity.
Questionnaire
Pain score on a scale of 1 to 10, where 1 indicates no pain and 10 indicates worst possible pain.
Sponsors and contacts
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