Health TrialsbyHealthPanel

Speech-in-noise Perception in Autism and Fragile X

ConditionsAutism Spectrum DisorderFragile X Syndrome
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age15-35
SponsorChildren's Hospital Medical Center, Cincinnati

About this trial

The goal of this study is to identify which brain regions are active during speech-in-noise perception, as well as how those regions interact. The investigators are studying brain activation during speech-in-noise in autism and controls as well as individuals with Fragile X Syndrome. The main question\[s\] it aims to answer are: 1) How does the brain's response to background noise affect a person's ability to understand speech? 2) Can visual cues improve hearing in background noise?

Participants will complete the following:

* hearing tests * cognitive and behavioral measures * questionnaires about their symptoms * both passive and active hearing tasks while brain activity is recorded with a neuroimaging cap Results will be compared between individuals with autism with and without Fragile X Syndrome as well as individuals without autism.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

normal audiograms (PTA ≤ 20 dB HL)

corrected 20/20 vision (Snellen chart)

no history of premature birth (prior to 36 weeks gestation)

no medications known to affect EEG signal

Disqualifiers

Hearing loss or uncorrected vision loss

history of premature birth (prior to 36 weeks gestation)

Trial design

Design model

Single group

Treatments tested in this trial

  • Mismatch negativity

    Behavioral

    Event related potentials are compared between frequent and infrequent speech sounds (i.e., "ba" vs "da").

Treatment groups

60 Participants
are divided into 1 treatment group
Group A: Speech SoundsExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Speech reception threshold for single digits in noise- auditory only

The SRT is the ratio between the loudness of speech and the loudness of background noise in decibels at which a participant can correctly report the digit that is presented at 50% accuracy.

Time frame
Baseline
2

Speech reception threshold for single digits in noise- with visual stimuli

The SRT is the ratio between the loudness of speech and the loudness of background noise in decibels at which a participant can correctly report the digit that is presented at 50% accuracy. A higher SRT indicates more difficulty hearing speech in background noise

Time frame
Baseline
3

Scaled score for auditory attention subtest

This task is from the Woodcock Johnson III. In this task, participants point to a picture after hearing a word presented in background noise, and accuracy is compared to same-age norms. Scores range from 1-19, with higher scores indicating better accuracy.

Time frame
Baseline
4

correlation between neural activation to speech (fNIRS) and neural differentiation of speech-in-noise (ERP)

Percent change in oxygenation in auditory cortex while hearing speech alone will be correlated with amplitude of the mismatch negativity to deviant sounds. This correlation reflects how neural activation affects neural differentiation for each individual participant

Time frame
Baseline

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Children's Hospital Medical Center, Cincinnati

Lead sponsor

Source ClinicalTrials.gov
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