Health TrialsbyHealthPanel

Speech Learning and Speech Production in Parkinson's Disease

ConditionParkinson's Disease
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age45+
SponsorState University of New York at Buffalo

About this trial

Parkinson's disease, a common movement disorder that results from a breakdown in the brain, often leads to challenges with talking, but less is known about the relationship between difficulties with talking and difficulties with learning to understand speech. By linking these two abilities in individuals with Parkinson's disease using a precision medicine approach, this project seeks to build a basis for new therapies that help people with Parkinson's disease both understand better and speak more clearly.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Diagnosis of Parkinson's disease

Native speaker of North American English

Use a drug that includes levodopa

Resident of the United States

Disqualifiers

Any history of language, hearing or speech disorder outside of Parkinson's disease

Other gross neurological impairment such as Alzheimer's disease or stroke

Significant hearing loss and/or use of a hearing aid or cochlear implant

Trial design

Design model

Single group

Treatments tested in this trial

  • Intensity learning

    Behavioral

    Participants will be asked to pair sentences that vary in their sound intensity to one of three colored squares (red, yellow, or blue)

  • Intensity discrimination

    Behavioral

    Participants will hear two sentences that are either the same or different in their sound intensity and will be asked to indicate whether the sentences were of the same or different intensities

  • Rate learning

    Behavioral

    Participants will be asked to pair sentences that vary in their spoken rate to one of three colored squares (red, yellow, or blue)

  • Rate discrimination

    Behavioral

    Participants will hear two sentences that are either the same or different in their spoken rate and will be asked to indicate whether the sentences were of the same or different rates

Treatment groups

50 Participants
are divided into 1 treatment group
Group A: Learning and DiscriminationExperimental treatment 4 interventions

Trial outcomes

Primary outcomes

1

Mean dB SPL

The mean speech intensity (in dB SPL) will be assessed using a recording of spoken sentences and a spoken paragraph.

Time frame
Day 1
2

Standard deviation dB SPL

The standard deviation of participant's speech intensity (in dB SPL) will be assessed using a recording of spoken sentences and a spoken paragraph.

Time frame
Day 1
3

Speaking rate

The speaking rate (in syllables/second) will be assessed using a recording of spoken sentences and a spoken paragraph.

Time frame
Day 1
4

Articulation rate

The articulation rate (in syllables/second after removing pauses) will be assessed using a recording of spoken sentences and a spoken paragraph.

Time frame
Day 1

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

State University of New York at Buffalo

Lead sponsor

Source ClinicalTrials.gov
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