Spirometry ,diaphragmatic Ultrasound and Skeletal Muscle Mass in Patients with Chronic Obstructive Pulmonary Disease

ConditionsCOPD Ultrasound Therapy; Complications

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexMale

Age41-70

SponsorAssiut University

About this trial

* The primary objective is to evaluate the use of diaphragmatic function and skeletal muscle mass by ultrasound as a tool to establish the diagnosis of COPD and assess the severity of the disease. * The secondary objective is to compare diaphragmatic function, Skeletal muscle mass, and spirometry results in patients with COPD.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

This group include healthy volunteers who aged ≥ 40 years .

This include stable COPD Patients who will be diagnosed by GOLD 2024 and last excerbation ≥ 6weeks .

Disqualifiers

Patients with disorders that may affect diaphragmatic function as

Musculoskeletal / neurological disorders

diaphragmatic eventration \ hiatus hernia

morbid obesity

Trial population

Two groups will be enrolled in the study; the first group will include healthy volunteers who aged ≥ 40 years\& the second group will include stable COPD Patients of the same age group

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

ultrasound, spirometry
Device
Ultrasound assessment of 1. diaphragmatic excursion:-the probe will be angled medially ,cranially , and dorsally so that the ultrasound beam reaches the posterior third of the diaphragm, in B-mode.Then, then M-mode exploration line will be placed perpendicular to the diaphragmatic dome to obtain maximum excursion . 2. (Tdi) will be measured using a high-frequency linear probe (10 MHz) placed on (ZA).The probe will be angled perpendicular to the lateral chest wall and placed between the midaxillary and anterior axillary lines at the eighth or ninth intercostal space. 3. Quadricep\|rectus femoris muscle assessment will be done by placing the transducer perpendicular to the long axis of the thigh. * Spirometry:-will be performed thrice by experienced technicians at our pulmonary function laboratory. Patients will be asked to take a maximal inspiration and then to forcefully expel air for as long and as quickly as possible.

Treatment groups

64 Participants

are divided into 2 treatment groups

Group A: control group1 intervention

Group B: study group1 intervention

Trial outcomes

Primary outcomes

to study the correlation between diaphragmatic excursion and FEV1

In the COPD group,The aim is to assess the correlation between diaphragmatic excursion and FEV1

Time frame

Day 1

Secondary outcomes

correlation between diaphragmatic muscle function , skeletal muscle mass and duration of hospital stay

correlation between diaphragmatic excursion measured by thoracic ultrasound in cm , quadriceps muscle thickness measured by ultrasound in cm and duration of hospital stay (in days)

Time frame

Day 1

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: