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St. Paul's Advanced Resection Center Cohort for Colorectal Neoplasia (SPARC-C)

ConditionsColon AdenomaColon PolypColon Lesion
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of British Columbia

About this trial

The SPARC-C study is a prospective, multi-institutional observational study of patients referred for the management of large (≥ 20mm) non-pedunculated colorectal polyps (LNPCPs). Patients are managed consistent with current standards of care. Prospectively collected data includes: patient clinicodemographic details, lesion details, procedural details, and clinical outcomes.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Patients ≥ 18 years of age referred for the management of an LNPCP

Able to provide informed consent.

Disqualifiers

Unable to provide informed consent

Pregnant or lactating women.

Trial population

Patients ≥18 years of age who have been referred to St. Paul's Hospital from 2022 to 2032 for management of a large (≥20mm) non-pedunculated colorectal polyp (LNPCP).

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Endoscopic tissue resection

    Procedure/Surgery

    Endoscopic resection techniques for removal of large polyps

Treatment groups

3,500 Participants
are divided into 1 treatment group
Group A: Large non-pedunculated colorectal polyp (LNPCP)1 intervention

Trial outcomes

Primary outcomes

1

Technical Success of Endoscopic Procedure

Complete removal of all visible polypoid tissue during index procedure.

Time frame
Intra-procedure
2

Clinical Success of Endoscopic Procedure

Technical success and the avoidance of surgery for large non-pedunculated colorectal polyps (LNPCPs) referred for endoscopic resection, assessed at first surveillance colonoscopy. LNPCPs with features consistent with invasive disease and directly referred for surgery are excluded.

Time frame
6 months

Secondary outcomes

1

Peri-Procedural Adverse Outcomes

Frequency and management of peri-procedural adverse outcomes including clinically significant intra-procedural bleeding, significant deep mural injury, clinically significant post-resection bleeding, delayed perforation, recurrence, and referral to surgery.

Time frame
6 months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of British Columbia

Lead sponsor

CentraCare

Collaborator

Hadassah Medical Organization

Collaborator

Vancouver Coastal Health Research Institute

Collaborator

Providence Healthcare

Collaborator

Source ClinicalTrials.gov
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