Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT ( KETZEREI )
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversität Münster
About this trial
Acute kidney injury (AKI) is a well-recognized complication in critically ill patients, which often leads to the necessity of mechanical kidney support (CRRT).
In current therapeutic regimes, CRRT is used to strictly prevent azotaemia. Thus recent clinical observations, as well as data from animal testing suggest a link between controlled azotaemia and faster renal recovery in AKI patients.
The aim of the study is to improve renal recovery.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adult patients (age ≥18 years)
Critically ill patients with AKI + in need of CRRT
Written informed consent
Disqualifiers
Chronic dialysis dependency
Chronic kidney disease with estimated glomerular filtration rate (eGFR) <30 ml/min/1.73m²
severe liver cirrhosis (Child-pugh C)
severe acidosis (pH < 7,20 at study enrolment)
Trial design
Design model
Parallel
Treatments tested in this trial
Effluent dose of CRRT
Other interventionThe effluent dose of the CRRT will be performed according to study group for 7 days or up to the end of CRRT, whatever occurs first.
Treatment groups
165 Participants
are divided into 2 treatment groupsGroup A: Intervention GroupExperimental treatment 1 intervention
Group B: Control GroupActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Number of days alive and free from CRRT
Time frame
Between Randomization and day 28Secondary outcomes
1
Number of Adverse Events (rooted in uraemia, i.e. throwing up, seizures, uremic coma etc.)
Time frame
Between randomization and day 282
Number of days with renal replacement therapy
Time frame
Between randomization and day 283
Length of Intensive Care Unit (ICU) stay
Time frame
Between randomization and day 284
Length of Hospital stay
Time frame
Between randomization and day 28Sponsors and contacts
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Source ClinicalTrials.gov