Standard Oxytocin Versus High Dose Oxytocin to Control Postpartum Hemorrhage in High Risk Pregnancy During Elective Cesarean Section

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age20-45
SponsorAin Shams University

About this trial

Controlling hemorrhage during and after a cesarean section reduces significantly maternal mortality and morbidity and the present study is important for detection of the effectiveness of routinely increasing the oxytocin dose instead of using the standard dose only in preventing postpartum hemorrhage and additional use of uterotonics in the first 24 hours after cesarean section for high risk pregnancy.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

- Medical disorders ie: Hypertensive diseases with pregnancy - Diabetes Mellitus - Collagen diseases - Coagulopathies - Cardiac diseases - Anemia

History of postpartum hemorrhage

Placental disorders ie: placenta previa

Infertility and ICSI

Disqualifiers

- Oxytocin Allergy

Normal uncomplicated pregnancy

Emergency cesarean section

Exhausted uterus due to trial of normal labor

Trial design

Design model

Parallel

Treatments tested in this trial

  • Oxytocin

    Drug

    will receive 10 IU oxytocin intravenous bolus over one min and infusion of 10 IU oxytocin in 500 ml of 0.9 saline over four hours.

Treatment groups

39 Participants
are divided into 2 treatment groups
Group A: Group A (standard oxytocin dose)Active comparator 1 intervention
Group B: Group B (high dose oxytocin)Active comparator 1 intervention

Trial outcomes

Primary outcomes

1

blood loss

measure blood in suction, towels and pads

Time frame
at the end of the operation

Secondary outcomes

1

haemoglobin

by laboratory asessment

Time frame
immediate preoperative
2

haemoglobin

by laboratory asessment

Time frame
6 hours postoperative

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

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