Standardising and Simplifying the Global Leadership Initiative on Malnutrition (GLIM) for Its More General Application

ConditionMalnutrition
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Tartu

About this trial

This observational study of aims to test whether and how the results of GLIM change when using different approaches and methods to carry out its components.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age of 18+ years

Able and willing to sign the consent form

Inpatients of the Tartu University Hospital

Admitted within 72 hours before enrolment

Disqualifiers

Age of <18 years

Inability or refusal to sign the consent form

Pregnant or lactating women

More than 72 hours passed since admission

Trial population

Inpatients of day patients admitted to the Tartu University Hospital.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Nutrition screening and assessment

    Diagnostic test

    The patient is interviewed for changes in body weight in the last six months and food intake in the last two weeks. The investigator evaluates the patient's diet, symptoms related to their nutritional status, and functional capacity according to the Subjective Global Assessment (SGA). The SGA tool itself is completed by the researcher. Height and weight of the patient are measured, if not yet recorded, and BMI is calculated. The patient's muscle mass is measured using mid-upper arm circumference (MUAC), calf circumference (CC) and bioelectrical impedance (BIA), and their muscle function assessed using hand grip strength.

Treatment groups

300 Participants
are divided into 1 treatment group
Group A: Inpatients of the Tartu University Hospital1 intervention

Trial outcomes

Primary outcomes

1

Subjective Global Assessment (SGA) defined malnutrition

Subjective Global Assessment (SGA) can be considered a method that is close to a "gold standard" for malnutrition assessment. Therefore, the study will analyse how different approaches to screening and muscle mass measurement affect the performance of GLIM in detecting Subjective Global Assessment (SGA) defined malnutrition.

Time frame
baseline, pre-intervention/procedure/surgery
2

One-year mortality

One year after the data collection, we will look at the patient records to collect the 1-year mortality data. This will give information about whether and how different approaches to components of GLIM affect its ability to predict one-year mortality.

Time frame
through study completion, an average of 1 year
3

Computed tomography (CT) defined muscle mass

One of the GLIM criteria is "reduced muscle mass", and this study will investigate how muscle mass measured with simpler methods compares against muscle mass measured with CT.

Time frame
baseline, pre-intervention/procedure/surgery
4

DEXA defined muscle mass

One of the GLIM criteria is "reduced muscle mass", and this study will investigate how muscle mass measured with simpler methods compares against muscle mass measured with DEXA.

Time frame
baseline, pre-intervention/procedure/surgery

Secondary outcomes

1

Bioelectrical impedance (BIA) defined muscle mass

One of the GLIM criteria is "reduced muscle mass", and this study will investigate how muscle mass measured with simpler methods compares against muscle mass measured with BIA.

Time frame
baseline, pre-intervention/procedure/surgery

Other outcomes

Sponsors and contacts

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University of Tartu

Lead sponsor

Tartu University Hospital

Collaborator