Standardization of a Platform of Preclinical Models Derived From NSCLC Patients
ConditionNon-Small Cell Lung Cancer
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorRegina Elena Cancer Institute
About this trial
Characterize and trace innovative nutraceuticals based on microencapsulated resveratrol and Cynara cardunculus extract, using preclinical models such as organotypic tissue slices and tumoroids created from tumor fragments derived from patients with non-small cell lung cancer. This will enable the development of combination therapies to increase the efficacy of immunotherapy in NSCLC and reduce side effects that lead to treatment discontinuation.
The market implementation of these products may offer unique advantages, including increased clinical efficacy, improved tolerability of immune checkpoint inhibitors, reduced healthcare costs, improved quality of life for patients and their families, traceability of naturally derived products, and environmental sustainability.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients over 18 years of age;
Patients diagnosed with resectable NSCLC who will undergo curative surgery;
Patients who give written informed consent (study participation and data processing).
Disqualifiers
Previous malignancies;
Previous systemic treatments.
Trial population
Patients with untreated NSCLC who will undergo curative surgery
Trial design
Design model
Other
Time perspective
Prospective
Treatments tested in this trial
Not listed
Trial groups
5 Participants
are grouped into 1 trial groupGroup A: Patients with untreated non-small cell lung cancer
Trial outcomes
Primary outcomes
1
Efficacy of microencapsulated nutraceutical compounds.
To investigate the efficacy of novel microencapsulated nutraceutical compounds in combination with immunotherapy in patients with lung cancer. Efficacy is measured as directly proportional to the binding created between the drug and the receptor.
Time frame
9 monthsSponsors and contacts
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Regina Elena Cancer Institute
Lead sponsor
University of Catanzaro
Collaborator
Source ClinicalTrials.gov