About this trial
The goals of our StepuP project are:
1. To understand the kinematic and neural mechanisms underlying walking improvements due to treadmill training with and without VR-enabled gait adaptations in people with PD; 2. To assess to what extent improvements in walking due to treadmill training, as measured in the laboratory, transfer to improvements in daily life mobility; 3. To understand the mechanisms underlying the transfer from improvements in walking to improvements in mobility in daily life in people with PD; 4. To understand for whom treadmill training improves walking characteristics in the laboratory and for whom it does not, and to understand for whom treadmill training improves mobility in daily life and for whom it does not.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Diagnosis of Parkinson's disease according to the MDS World Movement Disorders Society criteria Disease severity H&Y I-III
Score section 3.10 (ability to walk) MDS-UPDRS 3.10 ≥ 1
MoCA cognitive assessment > 15
Stable cardiovascular condition, ability to perform aerobic activity at low to moderate intensity
Disqualifiers
Moderate or severe depression (BDI-II ≥18)
Orthopedic diseases and other diseases that affect the quality of walking, at the decision of the researcher
Trial design
Single group
Treatments tested in this trial
VR
DeviceVirtual reality that simulates obstacles on the road during walking
Treatment groups
Trial outcomes
Primary outcomes
motion capture
Kinematic data will be collected using a Qualisys or Vicon motion capture system at a sampling frequency of 100 Hz.
describe brain activity by EEG cap
EEG recordings will be made using a 64-channel or 128 channel EEG cap
describe muscles activity by EMG electrodes
Bipolar EMG electrodes will be placed on the leg muscles. EMG data will be recorded at a sample frequency available for each system around 2000 Hz.
Secondary outcomes
clinical trial TUG
standard time-up-and-go test
clinical trial walk test
2-minute walk test
clinical trial MiniBESTest
balance and fall risk
mGES questionnaire
modified gait efficacy scale
Locations
Sponsors and contacts
Click on the lead sponsor to view all of their trials.
This trial is not recruiting at the moment. You can still explore other options: