Health TrialsbyHealthPanel

Stimulus Equivalence Learning in Acquired Brain Injury.

ConditionAcquired Brain Injury (Including Stroke)
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorKlimmendaal Revalidatiespecialisten

About this trial

Stimulus Equivalence Learning (SEL) is a form of learning in which stimuli (such as words, pictures, or sounds) become linked to one another in memory, even though this specific connection has not been directly taught. In a typical SEL task, two relations are taught explicitly (A→B and A→C), and the untrained relation (B→C) is then tested. This indirect relation is not intentionally or consciously learned and is considered a form of implicit learning. The principle of stimulus equivalence learning is still rarely applied in cognitive rehabilitation after acquired brain injury (ABI), with the exception of a few small (N=1) treatment studies that have shown positive effects. However, it remains unclear to what extent ABI may affect the ability to acquire stimulus equivalence.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

None

Disqualifiers

None

Trial population

ABI patients (\>3 months post-injury), including stroke, traumatic brain injury, brain tumor, encephalitis, and out-of-hospital cardiac arrest (OHCA).

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

40 Participants
are grouped into 2 trial groups
Group A: healthy controls
Group B: acquired brain injury

Trial outcomes

Primary outcomes

1

Modified Rutgers Equivalence Learning Task (mRAET)

The original RAET is an experimental paradigm in which faces have to be paired with colored fish. For the current study, this task has been adapted into a more ecologically valid version focused on medication intake, in which relationships are learned between the shape of a pill, the function of the pill, the time of intake, and the (fictional) brand name.

Time frame
Day 1

Secondary outcomes

1

Location Learning Test (LLT)

The LLT is a test that can be used to measure episodic spatial memory for object locations. Normalized scores for immediate and delayed spatial memory are computed (percentiles 0-100).

Time frame
Day 1
2

Wechsler Adult Intelligence Scale IV-NL digit span (WAIS-IV-NL DS)

The digit span is a measure of verbal working memory. Normalized standard scores can be computed (range 0-19, mean: 10, standard deviation: 3).

Time frame
Day 1
3

Everyday memory questionnaire-revised (EMQ-R)

This is a 13-item scale of the everyday memory functioning.

Time frame
Day 1
4

Trial Making Test

The Trail Making Test (TMT) is a neuropsychological test that measures processing speed, visual attention, and task switching.

Time frame
Day 1

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Klimmendaal Revalidatiespecialisten

Lead sponsor

Donders Centre for Cognitive Neuroimaging

Collaborator

Source ClinicalTrials.gov
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