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Stockholm Myocardial Infarction with Nonobstructive Coronaries Study 3

ConditionMyocardial Infarction with Nonobstructive Coronary Arteries
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age35-79
SponsorKarolinska Institutet

About this trial

The present pilot study will investigate the prevalence of CMD in an unselected cohort of patients with the working diagnosis MINOCA and to study if the diagnostic yield can be improved by adding adenosine to the CMR investigation. Patient will be their own controls.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

a suspected diagnosis of MINOCA or takotsubo syndrome with coronary angiography without diameter stenosis ≥50%

age 35-80 years

reading and writing proficiency in Swedish

Disqualifiers

Claustrofobia

Arrythmia and/or pacemaker (atrial fibrillation and AV-block I- III)

Asthma or severe chronic obstructive lung disease

eGFR < 30 ml/min

Trial design

Design model

Single group

Treatments tested in this trial

  • Cardiac magnetic resonance imaging to study coronary microvascular dysfunction

    Diagnostic test

    Myocardial perfusion mapping will be investigated after administration of adenosine

Treatment groups

85 Participants
are divided into 1 treatment group
Group A: Patients with MINOCA undergoing CMROther 1 intervention

Trial outcomes

Primary outcomes

1

Diagnostic yield

To increase the diagnostic yield of CMR imaging in MINOCA as a working diagnosis

Time frame
Through investigation completion, usually 2 hours

Secondary outcomes

1

Prevalence of CMD in MINOCA

To determine the proportion of patients with the working diagnosis of MINOCA who have CMD.

Time frame
Through investigation completion, usually 2 hours
2

Prevalence of CMD in different final MINOCA diagnoses

To study the proportions of CMD in patients with a CMR imaging diagnosis of myocardial infarction, Takotsubo, respectively myocarditis and compare them with the results from a healthy control group

Time frame
Through investigation completion, usually 2 hours
3

Angina pectoris

To investigate the occurrence of angina pectoris before inclusion and after 3 months and relate it to CMD

Time frame
3 Months

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Karolinska Institutet

Lead sponsor

Region Stockholm

Collaborator

Source ClinicalTrials.gov
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