Strength Training and Resveratrol
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60+
SponsorTexas Tech University
About this trial
The main goal of this study is to find out if supplementing with resveratrol improves skeletal muscle adaptations to strengthening exercise (resistance training or strength training) in adults age 60+, and to determine whether circulating vehicles of inter-organ communication (extracellular vesicles) and their cargo might help explain those responses. The investigators will also examine whether resveratrol supplementation improves blood vessel function and cognitive function (brain health) in response to strength training.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age 60+
Minimally active (less than 1 hour of structured exercise/week other than walking)
No resistance training for the previous 6 months
Not currently taking resveratrol supplements
Disqualifiers
Medical complications that could increase risk during exercise (e.g., cardiovascular disease, uncontrolled hypertension, type 1 or 2 diabetes, orthopedic contraindication to exercise, kidney disease, etc.)
Cannabis or nicotine use
Consume more than 7 alcohol-containing beverages per week
Trial design
Design model
Parallel
Treatments tested in this trial
Resistance training
BehavioralAfter pre-testing, participants will perform full-body strength training three times per week for two 6-week blocks. The acute program variables (sets, repetitions, training frequency) will follow a non-linear periodized, progressive design consisting of muti-joint and single-joint exercises. Exercise stress will be varied by using different exercises and loads. The two training blocks will be separated by a mid-intervention testing week, allowing for the study team to monitor participants' progress, communicate progress to participants to promote adherence, and adjust target loads as appropriate for the second half of the intervention. An additional testing week will follow the second 6-week block.
Resveratrol 500 mg oral once daily.
Dietary supplementParticipants will be randomized to consume resveratrol (500 mg) daily for 14 weeks (two 6-week blocks of resistance training \[supervised, full-body, 3 days/week\] + one testing week \[3 days\] following each block) after the pre-testing period. Participants will be provided with 7 days' worth of supplements at a time in pre-filled pill boxes. Pill boxes will be refilled weekly and adherence monitored.
Placebo
Dietary supplementParticipants will be randomized to consume placebo capsules (cellulose, visually identical to resveratrol capsules) daily for 14 weeks (two 6-week blocks of resistance training \[supervised, full-body, 3 days/week\] + one testing week \[3 days\] following each block) after the pre-testing period. Participants will be provided with 7 days' worth of supplements at a time in pre-filled pill boxes. Pill boxes will be refilled weekly and adherence monitored.
Treatment groups
36 Participants
are divided into 2 treatment groupsGroup A: Resveratrol (RSV) groupExperimental treatment 2 interventions
Group B: PlaceboPlacebo comparator 2 interventions
Trial outcomes
Primary outcomes
1
Circulating extracellular vesicle microRNA profile
Circulating extracellular vesicles will be isolated from plasma and their microRNA cargo will be sequenced.
Time frame
During pre-, mid-, and post-testing (each separated by about 6 weeks)2
Muscle torque
Participants will be instructed to try and straighten their leg, against resistance, as forcefully as possible and maximal torque of the quadriceps assessed using a dynamometer.
Time frame
During pre-, mid-, and post-testing (each separated by about 6 weeks)3
Muscle fatigability
Participants will perform 32 repetitions of knee extensions on a dynamometer and the change in torque from the beginning to the end will be used to indicate fatigability.
Time frame
During pre-, mid-, and post-testing (each separated by about 6 weeks)4
Muscle strength
Participants will perform submaximal testing to assess strength on key exercises included in the strength training protocol.
Time frame
During pre-, mid-, and post-testing (each separated by about 6 weeks)Secondary outcomes
1
Waist-to-hip ratio
Waist and hip circumferences measured using measuring tape
Time frame
During pre-, mid-, and post-testing (each separated by about 6 weeks)2
Vascular function
Flow-mediated dilation
Time frame
During pre-, mid-, and post-testing (each separated by about 6 weeks)3
Cognitive function
Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)
Time frame
During pre-, mid-, and post-testing (each separated by about 6 weeks)4
Grip strength
Handgrip dynamometry
Time frame
During pre-, mid-, and post-testing (each separated by about 6 weeks)Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Texas Tech University
Lead sponsor
National Strength and Conditioning Association
Collaborator
Source ClinicalTrials.gov