Structured Inpatient Physiotherapy in High-Risk Coronary Artery Bypass Grafting Patients
ConditionCABG
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-90
SponsorBezmialem Vakif University
About this trial
Coronary artery bypass grafting (CABG) may be associated with prolonged recovery, particularly in high-risk patients. Although preoperative rehabilitation has shown promising results, evidence remains limited because of heterogeneous intervention protocols and variations in postoperative care. This study aims to investigate the effects of a structured inpatient physiotherapy program initiated at least two days before surgery and continued postoperatively, compared with the same structured physiotherapy program provided only during the postoperative period, in high-risk CABG patients. The primary outcome is hospital length of stay. Secondary outcomes include intensive care unit length of stay, C-reactive protein, neutrophil-to-lymphocyte ratio, hemoglobin, dyspnea, and fatigue.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Adults aged 18 years or older.
Scheduled to undergo elective coronary artery bypass grafting (CABG).
Disqualifiers
Planned redo CABG surgery.
Severe neurological or orthopedic conditions limiting mobilization.
Severe cognitive impairment.
Hemodynamic instability.
Trial design
Design model
Parallel
Treatments tested in this trial
Preoperative and Postoperative Structured Inpatient Physiotherapy
Other interventionParticipants will receive a structured inpatient physiotherapy program initiated at least two days before CABG surgery and continued throughout postoperative hospitalization. The program includes breathing exercises, incentive spirometry, bronchial hygiene techniques, progressive early mobilization, and postural exercises. Before surgery, one supervised session will be provided daily, and participants will be instructed to repeat the program independently twice daily.
Postoperative Structured Inpatient Physiotherapy
Other interventionParticipants will receive the same structured inpatient physiotherapy program only during the postoperative hospitalization. The program includes breathing exercises, incentive spirometry, bronchial hygiene techniques, progressive early mobilization, and postural exercises.
Treatment groups
100 Participants
are divided into 2 treatment groupsGroup A: Preoperative and Postoperative Structured Inpatient PhysiotherapyExperimental treatment 1 intervention
Group B: Postoperative Structured Inpatient PhysiotherapyActive comparator 1 intervention
Trial outcomes
Primary outcomes
1
Hospital Length of Stay
Postoperative hospital length of stay, defined as the number of days from surgery until hospital discharge.
Time frame
From surgery until hospital discharge (approximately 7-14 days)Secondary outcomes
1
Intensive Care Unit Length of Stay
Length of stay in the intensive care unit, measured in days from admission to discharge from the intensive care unit.
Time frame
From surgery until discharge from the intensive care unit (approximately 1-5 days)2
Hemoglobin
Hemoglobin concentration measured as part of routine clinical laboratory testing and expressed in grams per deciliter (g/dL).
Time frame
Baseline (preoperative), through hospital discharge (up to approximately 30 days after surgery), and 7-10 days after hospital discharge.3
C-Reactive Protein (CRP)
Serum C-reactive protein concentration measured as part of routine clinical laboratory testing and expressed in milligrams per liter (mg/L) to assess postoperative inflammatory response.
Time frame
Baseline (preoperative), through hospital discharge (up to approximately 30 days after surgery), and 7-10 days after hospital discharge.4
Neutrophil-to-Lymphocyte Ratio (NLR)
Neutrophil-to-lymphocyte ratio calculated by dividing the absolute neutrophil count by the absolute lymphocyte count. The NLR is a unitless index used to assess systemic inflammatory response.
Time frame
Baseline (preoperative), through hospital discharge (up to approximately 30 days after surgery), and 7-10 days after hospital discharge.Sponsors and contacts
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Source ClinicalTrials.gov