STSC-HybridAPC Trial
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorWestern Sydney Local Health District
About this trial
Margin thermal ablation after piecemeal EMR significantly reduces recurrence of large colorectal polyps. As recurrence rates are now low, the key implementation question relates to efficiency and reproducibility of different ablation techniques. This randomized controlled trial compares snare tip soft coagulation (STSC) with Hybrid APC (ERBE), with procedural time as the primary endpoint.
Eligibility criteria
Qualifiers
Age ≥18 years
Undergoing piecemeal EMR of a non-pedunculated colorectal lesion ≥20 mm in size
Macroscopically complete resection achieved prior to margin ablation (no visible residual adenomatous tissue at the resection base)
Ability to provide written informed consent
Disqualifiers
Lesions requiring en bloc resection by ESD
Lesions with suspected deep submucosal invasion based on endoscopic assessment (e.g., depressed morphology, non-lifting sign, NICE type 3 pattern, or equivalent advanced imaging criteria)
Inflammatory bowel disease with active colitis at the lesion site
Overt invasive carcinoma requiring surgical management
Trial design
Treatments tested in this trial
- Snare Tip Soft Coagulation (STSC)
- Hybrid APC (ERBE)
Treatment groups
140 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov