Studies in Amyotrophic Lateral Sclerosis (ALS) and Other Neurodegenerative Motor Neuron Disorders

ConditionAmyotrophic Lateral Sclerosis

Trial statusRecruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

Age18+

SponsorMayo Clinic

About this trial

The purpose of this study is to collect, from patients with sporadic and familial ALS and their family members, clinical data and blood samples for extraction of DNA, RNA, preparation of lymphocytes, plasma and serum to establish a repository for future investigations of genetic contributions to ALS pathogenesis. Blood samples for DNA extraction also would be collected from control subjects with no personal or family history of ALS phenotypes.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Clinical diagnosis of possible, laboratory-supported probable, probable or definite ALS according to modified EL Escorial criteria, suspected ALS according to original El Escorial criteria, or diagnosis of a neurodegenerative disorder with evidence of ALS plus extramotor features; OR

A clinical suspicion or referral for ALS;

> 18 years of age;

Willing and able to give signed informed consent or assent that has been approved by the Institutional Review Board (IRB).

Disqualifiers

Personal or family history of dementia or other neurodegenerative disease (Parkinson disease, Alzheimer disease, etc.);

Limited mental capacity rendering the subject unable to provide written informed consent or comply with standard phlebotomy procedures.

Trial population

Eligible subjects with ALS or suspected ALS or family history of ALS will be identified from patients seen in the Department of Neurology at Mayo Clinic Jacksonville. Inclusion criteria include standardized diagnostic criteria for ALS as used in ALS therapeutic trials and patients with clinically suspected ALS.

Trial design

Design model

Case-control

Time perspective

Cross-sectional

Treatments tested in this trial

Not listed

Trial groups

3,000 Participants

are grouped into 3 trial groups

Group A: ALS or Suspected ALS Patient

Group B: Blood Relative of ALS Patient

Group C: Healthy Control

Trial outcomes

Primary outcomes

Blood Collection

Total number of blood samples collected

Time frame

50 years

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Mayo Clinic

Lead sponsor

National Institute of Neurological Disorders and Stroke (NINDS)

Collaborator

Source ClinicalTrials.gov

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