The aim of the study was to explore potential pathways for recovery and adaptation of the motor cortex by examining cerebral blood flow characteristics and hemodynamic markers analyzed by functional near-infrared spectroscopy (fNIRS) in patients with hemiparesis after stroke. Participants in the study performed a simple stimulus-response task several times with one healthy and one paralyzed limb at different stages of basic rehabilitation. A group of healthy, age-matched volunteers participated in the same experiment to verify the stroke-related changes. The researchers recorded fNIRS signals, muscle activity using electromyography, and heart activity using electrocardiography.
None
The presence of superficial injury of head (S00-S09 International Classification of Diseases 10 (ICD-10).
The presence of mental, behavioural disorders (F00-F99 ICD-10).
Drug addiction in the past or at the moment.
The presence of diseases of the nervous system (G00-G99 ICD-10).
Patients undergoing rehabilitation at the Federal center of brain research and neurotechnologies, FMBA, Moscow, Russia
Case-control
Cross-sectional
Stimulus response task
Diagnostic testParticipants were tasked with performing a finger extension exercise that required pressing buttons in response to visual stimuli. In cases where physical movement was not possible, participants were instructed to imagine performing the task while focusing on their fingers.
Hemodynamic changes after stroke
In post-stroke subjects, an increase in blood flow and oxygenation was observed in sensorimotor cortical regions of both hemispheres during movement of the paretic limb. This observation may indicate that the healthy hemisphere contributes to the execution of movement.
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Skolkovo Institute of Science and Technology
Lead sponsor
Federal Center of Brain Research and Neurotechnologies of the Federal Medical Biological Agency of Russia
Collaborator
