Study of Individual Neurocognitive Changes Associated With the Training of the Working Memory.
ConditionMental Health
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-30
SponsorCentre Hospitalier St Anne
About this trial
8 participants including 2 pilots. The 2 pilot participants will each execute an MRI acquisition session in order to adjust the experimental paradigm
Eligibility criteria
This trial accepts healthy volunteersQualifiers
age between 18 and 30 years,
right-handedness (assessed using the Edinburgh Handedness Inventory),
native French speaker, affiliation with the French national health insurance system
provision of written informed consent prior to participation.
Disqualifiers
contraindications to MRI,
neurological or psychiatric disorders
history of traumatic brain injury
any geographical or psychological condition preventing full compliance with the study protocol.
Trial population
healthy adult volunteers aged 18 to 30 who have no contraindications to an MRI scan.
Trial design
Design model
Case-only
Time perspective
Other
Treatments tested in this trial
Not listed
Trial groups
No trial groups listed
Trial outcomes
Primary outcomes
1
Working memory performance - Cogmed
Cognitive trajectories will be characterized using performance measures derived from the home-based training.
Time frame
5 week.2
Working memory performance - CANTAB
Cognitive trajectories will be characterized using performance measures derived from the Spatial Span (SSP) task from the CANTAB battery, administered under standardized conditions at GHU Paris Psychiatry and Neurosciences.
Time frame
2 week3
Multimodal MRI data
Multimodal MRI data - including anatomical, resting-state, working memory (WM) task-based functional, and diffusion-weighted sequences - will be acquired repeatedly over a six-week period during WM training, as well as before and after the training phase.
Time frame
2 weekSecondary outcomes
1
executive functions performance
To enable complementary analyses of non-trained executive functions (EF), the participant will complete three tasks from the NIH Toolbox Cognitive Battery.
Time frame
1 week2
behavioral variables
At baseline, we will collect demographic and cognitive information including age, sex, years of education, and baseline cognitive performance. In addition, we will record a set of covariates related to the participant's state during the scanning session and within the 24 hours preceding each training session.
Time frame
5 week for most variablesSponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov