Study of Language Disorders and Interactions Between Mnesic Capabilities and Semantic Competencies in Patients With Psychosis

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age16-55
SponsorCentre Psychothérapique de Nancy

About this trial

This research concerns the study of language disorders of patients present in the spectrum of psychosis. It is indeed accepted that psychotic disorders are associated with language difficulties, which are only poorly highlighted thanks to reusable tools in clinical practice. These language disorders impact communication, and concern many linguistic domains, thus covering phonology, lexicon, semantics, morphosyntax and pragmatics. It therefore seems relevant to characterize these language disorders and to assess to what extent they interact with the other symptoms of the pathology, in particular the course of the thought disorder and the neuropsychological symptoms. In addition, this study is particularly interested in the interactions between working memory capacities and those related to syntax. It is intended for different patients suffering from psychotic disorders of different intensities, treated in the Psychotherapeutic Center of Nancy. Patients suffering from at-risk mental state (ARMS), first episode of psychosis (FEP) or schizophrenia will benefit from a complete language assessment, evaluating each domain mentioned above, on the expressive and understanding sides. The results of the language assessment will be compared with those of a control group in the same tests. They will also be analyzed with regard to the neuropsychological and psychiatric elements noted in the patient's medical file, in order to highlight possible associations between language skills, neuropsychological and psychiatric symptoms in this patient population.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Patient affiliated or entitled to a social security scheme

Patient having received informed information on the study and having co-signed, with the investigator, a consent to participate in the study

For minor participants, at least one of the parents or holders of parental authority having been informed of the study, having received the information note relating to it and not having objected to the participation of his or her child

Native language: French

Disqualifiers

Pregnant, parturient or nursing mother

Person deprived of liberty by a judicial or administrative decision

Person in a life-threatening emergency

Adult subject to a legal protection measure (guardianship, curatorship, safeguard of justice)

Trial design

Design model

Parallel

Treatments tested in this trial

  • Language assessment

    Behavioral

    The proposed speech and language therapy assessment will consist of a battery of standardized tests that speech and language therapists can use to assess the language skills in reception and expression of adult patients. Concerning the assessment of the interactions between working memory and semantic abilities, a complete protocol has been developed.

  • TLC - Scale for the Assessment of Thought, Language, and Communication

    Behavioral

    This scale is frequently used in psychiatry and is used to measure formal thought disorders in patients suffering from psychosis. As part of this study, it will be intended for patients suffering from schizophrenia

  • MINI - Mini International Neuropsychiatric Interview

    Behavioral

    This scale corresponds to a rapid assessment of the psychiatric and psychological state of patients. It helps detect any psychiatric disorders. Here, it will be offered to volunteers who are part of the control group.

  • CAST - Cannabis Abuse Screening Test

    Combination product

    The purpose of this questionnaire is to approximate participants' cannabis consumption and to assess any disorders associated with cannabis consumption. It will be offered to all participants, patients and healthy controls

Treatment groups

90 Participants
are divided into 3 treatment groups
Group A: early psychotic symptomsExperimental treatment 2 interventions
Group B: patients with schizophreniaExperimental treatment 3 interventions
Group C: healthy controlsExperimental treatment 3 interventions

Trial outcomes

Primary outcomes

1

language assessment performance score

complete speech therapy assessment evaluating each language domain. and is based on the completion of a speech therapy assessment test and on the assessment of language abilities by the experimental speech therapist.

Time frame
day 1

Secondary outcomes

1

CAARMS Speech Disorganization Severity Score

CAARMS: Comprehensive Assessment of At Risk Mental State

Time frame
day 1
2

Severity score for the disordered items of the course of thought of the SPI-A

SPI-A:Schizophrenia Proneness Instrument

Time frame
day 1
3

Severity score for speech disorganization and formal thought disorders on the TLC Scale

TLC: Thinking, Language and Communication Rating Scale

Time frame
day 1
4

Neuropsychological rating scales scores (CVLT)

CVLT (California Verbal Learning test) (quantitative variable): CVLT: number of correct recognitions

Time frame
day 1

Other outcomes

Sponsors and contacts

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