About this trial
This research concerns the study of language disorders of patients present in the spectrum of psychosis. It is indeed accepted that psychotic disorders are associated with language difficulties, which are only poorly highlighted thanks to reusable tools in clinical practice. These language disorders impact communication, and concern many linguistic domains, thus covering phonology, lexicon, semantics, morphosyntax and pragmatics. It therefore seems relevant to characterize these language disorders and to assess to what extent they interact with the other symptoms of the pathology, in particular the course of the thought disorder and the neuropsychological symptoms. In addition, this study is particularly interested in the interactions between working memory capacities and those related to syntax. It is intended for different patients suffering from psychotic disorders of different intensities, treated in the Psychotherapeutic Center of Nancy. Patients suffering from at-risk mental state (ARMS), first episode of psychosis (FEP) or schizophrenia will benefit from a complete language assessment, evaluating each domain mentioned above, on the expressive and understanding sides. The results of the language assessment will be compared with those of a control group in the same tests. They will also be analyzed with regard to the neuropsychological and psychiatric elements noted in the patient's medical file, in order to highlight possible associations between language skills, neuropsychological and psychiatric symptoms in this patient population.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Patient affiliated or entitled to a social security scheme
Patient having received informed information on the study and having co-signed, with the investigator, a consent to participate in the study
For minor participants, at least one of the parents or holders of parental authority having been informed of the study, having received the information note relating to it and not having objected to the participation of his or her child
Native language: French
Disqualifiers
Pregnant, parturient or nursing mother
Person deprived of liberty by a judicial or administrative decision
Person in a life-threatening emergency
Adult subject to a legal protection measure (guardianship, curatorship, safeguard of justice)
Trial design
Parallel
Treatments tested in this trial
Language assessment
BehavioralThe proposed speech and language therapy assessment will consist of a battery of standardized tests that speech and language therapists can use to assess the language skills in reception and expression of adult patients. Concerning the assessment of the interactions between working memory and semantic abilities, a complete protocol has been developed.
TLC - Scale for the Assessment of Thought, Language, and Communication
BehavioralThis scale is frequently used in psychiatry and is used to measure formal thought disorders in patients suffering from psychosis. As part of this study, it will be intended for patients suffering from schizophrenia
MINI - Mini International Neuropsychiatric Interview
BehavioralThis scale corresponds to a rapid assessment of the psychiatric and psychological state of patients. It helps detect any psychiatric disorders. Here, it will be offered to volunteers who are part of the control group.
CAST - Cannabis Abuse Screening Test
Combination productThe purpose of this questionnaire is to approximate participants' cannabis consumption and to assess any disorders associated with cannabis consumption. It will be offered to all participants, patients and healthy controls
Treatment groups
Trial outcomes
Primary outcomes
language assessment performance score
complete speech therapy assessment evaluating each language domain. and is based on the completion of a speech therapy assessment test and on the assessment of language abilities by the experimental speech therapist.
Secondary outcomes
CAARMS Speech Disorganization Severity Score
CAARMS: Comprehensive Assessment of At Risk Mental State
Severity score for the disordered items of the course of thought of the SPI-A
SPI-A:Schizophrenia Proneness Instrument
Severity score for speech disorganization and formal thought disorders on the TLC Scale
TLC: Thinking, Language and Communication Rating Scale
Neuropsychological rating scales scores (CVLT)
CVLT (California Verbal Learning test) (quantitative variable): CVLT: number of correct recognitions
Sponsors and contacts
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