Study aims to examine the effects of noninvasive brain stimulation on brain signals. This insight may have potential clinical implications for addiction, pain, and mental health populations. Participants will receive MRI and CT imaging. Participants receive low-intensity focused ultrasound (LIFU) to temporarily change brain activity. Participants then receive fMRI scans to measure changes in both resting and cognitive brain signaling using structured tasks. Heart rate, blood pressure, respiratory rate, and skin moisture is monitored. Participants complete a battery of questionnaires, both behavioral and symptom monitoring. The study takes place over 4 study visits.
Healthy volunteers, all ethnicities, who understand and speak English.
Claustrophobia (scanning environment may be uncomfortable).
Contraindications to MRI: including pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants.
Contraindications to CT: pregnancy
Active medical disorder or treatment with potential CNS effects (e.g. Alzheimer's)
Single group
Neuromodulation with low-intensity focused ultrasound
Other interventionapplication of LIFU to induce temporary neuromodulation, effects tested with resting state and task based fMRI scanning.
fMRI Signals - Cognition
Changes in fMRI signals of region of interest during a cognitive task
Executive function task performance
Testing effects of LIFU on altered task performance
Assess for changes in physiological measures
Monitoring for any changes in heartrate, blood pressure, respiratory rate, or galvanic skin response throughout testing
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