Study of Microbiological Diversity in Exhaled Air in COPD and Free of COPD
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-70
SponsorCentre Hospitalier Intercommunal Creteil
About this trial
COPD and non-COPD patients will be included in the study after collection of their non-objection. The exhalation will be collected to study the microbiological diversity of human exhalations.
a second collection for the year +1 will be made, at the same time (between October and March).
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patients with chronic obstructive pulmonary disease
Age: over 18
Absence of chronic obstructive pulmonary disease
Age: between 18 and 30 years old and between 45 and 70 years old
Disqualifiers
Taking certain medications in the month preceding the sample (antibiotics, systemic corticosteroids, immunosuppressants)
Person under guardianship or curatorship
Pregnant or breastfeeding women
Person unable to express his/her opposition, person deprived of liberty
Trial population
Subjects with chronic obstructive pulmonary disease (COPD) and no-COPD control subjects
Trial design
Design model
Case-control
Time perspective
Prospective
Treatments tested in this trial
collection of human exhalation
Other interventionthe collection of the exhalation will be carried out with a non-invasive device manufactured by a Chinese company. The collection of exhalation consists of the subject inhaling through the nose and exhaling gently through the mouth through a plastic straw for a time set at 5 min in the device
Treatment groups
240 Participants
are divided into 2 treatment groupsGroup A: Chronic Obstructive Pulmonary Disease (COPD)1 intervention
Group B: NO-Chronic Obstructive Pulmonary Disease1 intervention
Trial outcomes
Primary outcomes
1
Number and dominant bacterial species in human exhalations of COPD subjects and non-COPD subjects
number and bacterial species
Time frame
BaselineSecondary outcomes
1
Number and dominant bacterial species in human exhalations according to smoking status
number and bacterial species
Time frame
Baseline2
Number and dominant bacterial species in human exhalations according to age
number and bacterial species
Time frame
Baseline3
Number and dominant bacterial species in human exhalations for patients returning for consultation 1 year apart during the winter season
number and bacterial species
Time frame
1 yearSponsors and contacts
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Source ClinicalTrials.gov