Study of Predictive Factors Related to Prognosis of Patients With Ischemic Stroke Due to Large-artery Atherosclerosis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeUp to 80
SponsorTongji Hospital
About this trial
This is a single-center prospective cohort study of predictive factors related to prognosis of ischemic stroke due to large-artery atherosclerosis.
From March 1, 2021 to December 31, 2026, 1000 patients with ischemic stroke due to large-artery atherosclerosis who are admitted to the Department of Neurology or Neurosurgery, Tongji Hospital are going to be recruited. Detailed clinical data in emergency room and in-hospital will be obtained from the medical record reviews, and the National Institutes of Health Stroke Scale (NIHSS) and Modified Rankin Scale (mRS) score will be done by certified neurologists to assess the severity of the disease in acute stage and treatment outcome during the follow-up. All cases will undergo routine blood tests, brain magnetic resonance imaging (MRI) and cerebral vascular examination, such as TCD, CTA, HRMR or DSA. The investigators will analyze the in-hospital factors that could predict the outcome to provide more evidence-based suggestions in the treatment and prognosis of atherosclerotic ischemic cerebrovascular disease.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Ischemic stroke due to large-artery atherosclerosis has been proved by clinical symptoms and imaging examinations.
Symptomatic superior arch stenosis >50%
Asymptomatic superior arch stenosis was >70%
written informed consent was obtained from patients or their surrogates before enrollment.
Disqualifiers
Brain CT or MRI showing cerebral hemorrhage (excluded ischemic stroke with hemorrhage transformation)
With severe systemic disease, are expected to survive < 3 months
Patients will not able to provide continuous follow-up information
Trial population
Patients with ischemic stroke due to large-artery atherosclerosis admission to Department of Neurology and Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from March 1, 2021 - December 31, 2026
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
carotid artery stenting
Procedure/Surgerycommon treatments for carotid artery stenosis
carotid endarterectomy
Procedure/Surgerycommon treatments for carotid artery stenosis
Aspirin
Drugthe dosage and duration
Clopidogrel
Drugthe dosage and duration
Anticoagulant
Drugthe dosage and duration
Statin
Drugthe dosage and duration
PCSK9 inhibitor
Drugthe dosage and duration
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
all-cause mortality
Death during the follow-up in every single reason
Time frame
3-6 months after onset.2
Stroke of any kind
Brain CT or MRI scans will be used to measure whether there is any kind of stroke, including TIA, ischemic stroke, and hemorrhage
Time frame
3-6 months after onset.Secondary outcomes
1
Rehospitalization
The rehospitalized times of any circumstances except for admission to hospital only for examination per year will be used to measure the situation
Time frame
1 month to 24 months after onset.2
National Institute of Health stroke scale (NIHSS score)
The minimum value is 0, and maximum value is 42, and higher scores mean a worse outcome.
Time frame
1 month to 24 months after onset.3
modified Ranking score (mRS)
The minimum value is 0, and maximum value is 6, and higher scores mean a worse outcome.
Time frame
1 month to 24 months after onset.Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Source ClinicalTrials.gov