Study of Self-Recognition and Self/Other Distinction Disorders in Patients With Psychological Vulnerability
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age15-25
SponsorUniversity Hospital, Brest
About this trial
The main objective of this study is to establish whether there are differences in self-recognition and self/other distinction in subjects with psychological vulnerability compared to healthy volunteer controls.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Aged from 15 to 25 years
Subject meeting the Ultra High Risk criteria at CAARMS and / or SPI-A
Signature of the consent (participants and parents for minors)
Subject affiliated to the social security scheme or benefiting from such a scheme
Disqualifiers
History of epilepsy and / or migraine (due to the epileptogenic potential of light stimuli)
Refusal of participation of the minor even if the legal representatives want the subject to participate in the study
Claustrophobia
Wearing glasses
Trial design
Design model
Parallel
Treatments tested in this trial
Double mirror device ALTER-EGO
Other interventionThe patient and his matched healthy volunteer will be placed on each side of the double mirror device ALTER-EGO. Both sides will be lightened alternatively or at the same time by lights, so according to the light intensity, the subject will see himself in a mirror or the other person throw a classic window. The light intensity will vary from 0 to 100% and to 100% to 0% alternatively from each side of the mirror. At each 10% variation of one side, both patient and volunteer will have to answer that question : "who do you see more : him/her or yourself ?"
EASE test
Other interventionThe patient will have to answer the EASE test which is a specific test to detect patient with high risk of psychosis or schizophrenia
Treatment groups
34 Participants
are divided into 2 treatment groupsGroup A: PatientsOther 2 interventions
Group B: Healthy volunteersOther 1 intervention
Trial outcomes
Primary outcomes
1
Average of the three M1
Average of the three M1 thresholds obtained from the "round trip" manipulation repeated three times, the M1 threshold corresponding to the level of luminosity from which a subject begins to recognize himself when his own image gradually appears (during the passage of the condition glass in mirror condition).
Time frame
InclusionSecondary outcomes
1
The average of the three M2
The average of the three M2 thresholds obtained from the "round trip" manipulation repeated three times, the M2 threshold corresponding to the level of brightness from which a subject ceases to recognize himself to recognize the other (passage of the mirror mode to window mode).
Time frame
Inclusion2
Results to tests for early prodromal symptoms assessed by SPI-A (Schizophrenia Prediction Instrument for Adults)
• Hetero-questionnaire of SPI-A : intensity, type and frequency of symptoms : The answer "yes" to the COPER (Cognitive-Perceptive Basic Symptoms) and / or COGDIS (Cognitive Disturbances) criteria points to at risk mental state.
Time frame
Inclusion3
Results to tests for early prodromal symptoms assessed by PQ16 (Prodromal Questionnaire - 16)
• Self-administered questionnaire PQ16 : intensity, type and frequency of symptoms : The minimum score is 0 and maximum 16 meaning a higher state of risk.
Time frame
Inclusion4
Results to tests for early prodromal symptoms assessed by EASE(xamination of Anomalous Self-Experience)
• Self-experience anomalies evaluation scale : EASE, Parnas, 2003), until now not carried out as part of the routine monitoring of CEVUP (Consultation d'Evaluation de la VUlnérabilité Psychique = Psychic Vulnerability Assessment Consultation) patients : score between 0 and 57, the higher the score, the greater the risk of psychosis
Time frame
InclusionSponsors and contacts
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Source ClinicalTrials.gov